目的 观察杞菊润目颗粒联合地夸磷索钠滴眼液治疗干眼症的临床疗效。方法 选取2020年1月—2020年12月天津医科大学总医院收治的100例干眼症患者，根据随机数字表法将患者分为对照组（n=50）和治疗组（n=50）。对照组患者给予地夸磷索钠滴眼液，1～2滴/次，4次/d。治疗组患者在对照组的基础上口服杞菊润目颗粒，1袋/次，2次/d。两组均连续治疗8周。观察两组的临床疗效，比较两组治疗前后自觉症状评分、眼部症状指标和血清学因子的变化情况。结果 治疗后，治疗组总有效率是88.0%，显著高于对照组的68.0%（P<0.05）。治疗后，两组异物感评分、干涩评分、视疲劳评分、视物模糊评分及畏光评分均显著降低（P<0.05）；且治疗后，治疗组自觉症状评分低于对照组（P<0.05）。治疗后，两组泪膜破裂时间（BUT）、泪液分泌试验（SIT）均显著升高，但角膜荧光染色（FL）显著降低（P<0.05）；治疗后，治疗组眼表功能指标改善优于对照组（P<0.05）。治疗后，两组白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、白细胞介素-1β（IL-1β）均较治疗前显著降低（P<0.05）；治疗后，治疗组炎症因子水平低于对照组（P<0.05）。结论 杞菊润目颗粒联合地夸磷索钠滴眼液治疗干眼症具有较好的临床疗效，可有效改善眼表功能，促进症状改善，调节炎性因子水平，具有一定的临床推广应用价值。

Objective To observe the clinical effect of Qiju Runmu Granules combined with Diquafosol Sodium Eye Drops in treatment of xerophthalmia. Methods A total of 100 patients with xerophthalmia admitted to General Hospital of Tianjin Medical University from January 2020 to December 2020 were selected and divided into control group (n=50) and treatment group (n=50) according to random number table method. Patients in the control group were given Diquafosol Sodium Eye Drops, 1 — 2 drops/time, 4 times daily. Patients in the treatment group were po administered with Qiju Runmu Granules on the basis of the control group, 1 bag/time, twice daily. The clinical efficacy of the two groups was observed, and the changes of conscious symptom scores, ocular symptom indexes, and serological factors before and after treatment were compared. Results After treatment, the total effective rate of the treatment group was 88.0%, which was significantly higher than that of the control group (68.0%, P<0.05). After treatment, foreign body sensation score, dryness score, visual fatigue score, visual blur score, and photophobia score were significantly decreased in both groups (P<0.05). After treatment, symptom score of treatment group was lower than that of control group (P<0.05). After treatment, tear film rupture time (BUT) and tear secretion test (SIT) were significantly increased in both groups, but corneal fluorescence staining (FL) was significantly decreased (P<0.05). After treatment, the improvement of ocular surface function in the treatment group was better than that in the control group (P<0.05). After treatment, interleukin-6 (IL-6), tumor necrosis factor-α(TNF-α), and interleukin-1β (IL-1β) in two groups were significantly decreased compared with before treatment (P<0.05). After treatment, the levels of inflammatory cytokines in treatment group were lower than those in control group (P<0.05). Conclusion Qiju Runmu Granules combined with Diquafosol Sodium Eye Drops has a good clinical effect in treatment of xerophthalmia, and can effectively improve the ocular surface function, and also can promote the symptoms, regulate the level of inflammatory factors, which has a certain clinical application value.

R988.1

天津市科技发展指导性计划项目（TJSW2016013）