[关键词]
[摘要]
目的 探讨康复新液对放射性口腔溃疡患者免疫功能及炎性因子水平的影响。方法 选取2019年6月—2020年6月新余钢铁集团有限公司中心医院收治的84例放射性口腔溃疡患者,按照随机数字表法分为对照组和治疗组,每组各42例。对照组采用2.5 mg地塞米松+0.05 mg维生素B12+10 mL生理盐水混合液含服,每次口含时间10 min,3次/d。在此基础上治疗组口含康复新液10 mL,每次口含时间为5 min,而后吞下药液,3次/d。两组持续治疗至放疗结束后2周。观察两组的临床疗效,比较两组治愈时间和疼痛持续时间、免疫功能和炎性因子指标。结果 治疗后,治疗组总有效率是97.62%,显著高于对照组的76.19%(P<0.05)。治疗过程中,治疗组治愈时间、疼痛持续时间均显著短于对照组(P<0.05)。治疗后,两组CD3+、CD4+、CD4+/CD8+均显著升高,但CD8+均显著降低(P<0.05);治疗后,治疗组免疫功能指标改善优于对照组(P<0.05)。治疗后,两组肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、干扰素-γ(IFN-γ)均较治疗前显著降低(P<0.05);且治疗后治疗组炎性因子水平显著低于对照组(P<0.05)。结论 康复新液联合地塞米松、维生素B12治疗放射性口腔溃疡的疗效显著,能明显促进患者口腔疮面愈合,减轻疼痛和炎症反应,提高免疫功能,具有一定的临床推广应用价值。
[Key word]
[Abstract]
Objective To explore the effect of Kangfuxin Liquid on the immune function and inflammatory factor levels in treatment of radioactive oral ulcer. Methods A total of 84 patients with radioactive oral ulcer treated in Central Hospital of Xinyu Iron and Steel Group Co., Ltd from June 2019 to June 2020 were selected, and they were divided into control group and treatment group according to random number table method, with 42 patients in each group. Patients in the control group were given a mixture of 2.5 mg dexamethasone + 0.05 mg vitamin B12 + 10 mL normal saline for 10 min, 3 times daily. On this basis, patients in the treatment group were treated with 10 mL Kangfuxin Liquid, and the oral time was 5 min each time, then the liquid was swallowed, three times daily. Both groups were treated until 2 weeks after the end of radiotherapy. The clinical efficacy of the two groups was observed, and the cure time, pain duration, immune function, and inflammatory factors were compared between two groups. Results After treatment, the total effective rate of the treatment group was 97.62%, which was significantly higher than that of the control group (76.19%) (P<0.05). During the course of treatment, the cure time and pain duration in the treatment group were significantly shorter than those in the control group (P<0.05). After treatment, CD3+, CD4+, and CD4+/CD8+ in both groups were significantly increased, but CD8+ was significantly decreased (P<0.05). After treatment, the improvement of immune function indexes in treatment group was better than that in control group (P<0.05). After treatment, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-8 (IL-8), and interferon-γ (IFN-γ) in two groups were significantly decreased compared with before treatment (P<0.05). After treatment, the level of inflammatory factors in treatment group was significantly lower than that in control group (P<0.05). Conclusion Kongfuxin Liquid combined with dexamethasone and vitamin B12 has curative effect in treatment of radioactive oral ulcer, and can significantly promote the healing of the patient's oral wound, relieve pain and inflammation, and improve immune function, which has certain clinical application value.
[中图分类号]
R988.2
[基金项目]
新余市科技计划项目(20193090835)