目的 探讨黄豆苷元片联合巴曲酶注射液治疗突发性耳聋耳鸣的临床疗效。方法 选择2018年3月—2020年3月在郑州大学第二附属医院治疗的98例突发性耳聋耳鸣患者，根据药物使用的差别分成对照组和治疗组，每组各49例。对照组静脉滴注巴曲酶注射液，首次20 BU加入生理盐水100 mL，1次/2 d，维持剂量5 BU；治疗组在对照组基础上口服黄豆苷元片，50 mg/次，3次/d。两组患者均经3周治疗。观察两组患者临床疗效，比较治疗前后两组患者临床症状改善时间，血液流变学指标全血高切黏度、全血低切黏度、血浆黏度和红细胞压积水平，及PSQI、THI和SF-36评分。结果 经治疗，治疗组总有效率为97.96%，显著高于对照组的83.67%（P<0.05）。经治疗，治疗组耳鸣、眩晕、耳闷改善时间均早于对照组（P<0.05）。经治疗，两组全血高切黏度、全血低切黏度、血浆黏度及红细胞压积均显著降低（P<0.05），且治疗组降低最显著（P<0.05）。治疗后，两组患者PSQI评分和THI量表评分显著降低，而SF-36评分显著升高（P<0.05），且治疗组这些评分明显好于对照组（P<0.05）。结论 黄豆苷元片联合巴曲酶注射液治疗突发性耳聋耳鸣有着显著疗效，同时还能改善患者血液流变学和生活质量，具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy of Daidzein Tablets combined with batroxobin in treatment of sudden deafness and tinnitus. Methods Patients (98 cases) with sudden deafness and tinnitus in Second Affiliated Hospital of Zhengzhou University from March 2018 to March 2020 were divided into control (56 cases) and treatment (56 cases) groups according to the difference of drugs. Patients in the control group were iv administered with Batroxobin Injection, the initial dose was 20 BU added into normal saline 100 mL, once every 2 days, and the maintenance dose was 5 BU. Patients in the treatment group po administered with Daidzein Tablets on the basis of the control group, 50 mg/time, three times daily. Patients in two groups were treated for 3 weeks. After treatment, the clinical efficacy was evaluated, and the improvement time of clinical symptoms, hemorheological indexes of whole blood high shear viscosity, whole blood low shear viscosity, plasma viscosity, and hematocrit, the scores of PSQI, THI, and SF-36 in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group was 97.96%, which was significantly better than 83.67% of the control group (P<0.05). After treatment, the improvement time of tinnitus, vertigo and ear tightness in treatment group was earlier than that in control group (P<0.05). After treatment, the whole blood high shear viscosity, whole blood low shear viscosity, plasma viscosity, and hematocele were significantly decreased in two groups (P<0.05), and the decrease in treatment group was more significant (P<0.05). After treatment, the PSQI score and THI scale score in two groups were significantly decreased, while the SF-36 score were significantly increased (P<0.05), and these scores in treatment group were significantly better than those in control group (P<0.05). Conclusion Daidzein Tablets combined with Batroxobin Injection is effective in the treatment of sudden deafness and tinnitus, can also improve hemorheology and quality of life of patients, which has a certain clinical application value.

R987

河南省医学科技攻关计划项目（豫卫科[2017]13号）