目的 观察参芪降糖颗粒联合艾塞那肽注射液治疗2型糖尿病的临床疗效。方法 选取2018年10月—2020年8月郑州大学第一附属医院接收的120例2型糖尿病患者，按照随机数字表法将患者分为对照组和治疗组，每组各60例。对照组患者早、晚餐前60 min皮下注射艾塞那肽注射液，5 μg/次，2次/d。治疗组在对照组的治疗基础上口服参芪降糖颗粒，1袋/次，3次/d。两组患者连续治疗4周。观察两组临床疗效，比较两组治疗前后的血糖波动指标、血糖、胰岛素抵抗指标。结果 治疗后，治疗组的总有效率为88.33%，高于对照组的70.00%，差异有统计学意义（P<0.05）。治疗后，两组血糖标准差（SDBG）、全天平均血糖波动幅度（MAGE）、全天有效血糖波动次数（NGE）水平均降低，差异有统计学意义（P<0.05），且治疗组SDBG、MAGE、NGE水平低于对照组，差异有统计学意义（P<0.05）。治疗后，两组空腹血糖（FPG）、餐后2 h血糖（2 h PG）、糖化血红蛋白（HbAlc）水平均降低，差异有统计学意义（P<0.05），且治疗组FPG、2 h PG、HbAlc水平低于对照组，差异有统计学意义（P<0.05）。治疗后，两组胰岛素（FINS）、胰岛素抵抗指数（HOMA-IR）较治疗前下降，差异有统计学意义（P<0.05），且治疗组FINS、HOMA-IR低于对照组，差异有统计学意义（P<0.05）。结论 参芪降糖颗粒联合艾塞那肽注射液治疗2型糖尿病患者的效果显著，能够降低患者血糖，减轻胰岛素抵抗及改善血糖波动指数，安全性较高。

Objective To observe the clinical effect of Shenqi Jiangtang Granules combined with Exenatide Injectio in treatment of type 2 diabetes mellitus. Methods Patients (120 cases) with type 2 diabetes mellitus in the First Affiliated Hospital of Zhengzhou University from October 2018 to August 2020 were randomly divided into control and treatment groups, and each group had 60 cases. Patients in the control group were sc injection administered with Exenatide Injection at 60 min before breakfast and dinner, 5 μg/time, twice daily. Patients in the treatment group were po administered with Shenqi Jiangtang Granules on the basis of the control group, 1 bag/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and blood glucose fluctuation indexes, blood glucose and insulin resistance in two groups were compared before and after treatment. Results After treatment, the total effective rate of the treatment group was 88.33%, which was higher than that of the control group (70%), and the difference was statistically significant (P<0.05). After treatment, the levels of SDBG, MAGE, and NGE in two groups were decreased, and the difference was statistically significant (P<0.05). The levels of SDBG, MAGE, and NGE in the treatment group were lower than those in the control group, and the difference was statistically significant (P<0.05). After treatment, the levels of FPG, 2 h PG, and HbAlc in two groups were decreased, and the difference was statistically significant (P<0.05). The level of blood glucose related indicators FPG, 2 h PG, and HbAlc in the treatment group was lower than that in the control group, and the difference was statistically significant (P<0.05). After treatment, the FINS and HOMA-IR of two groups were decreased, and the difference was statistically significant (P<0.05). Insulin related indexes FINS and HOMA-IR of the treatment group were lower than those of the control group, and the difference was statistically significant (P<0.05). Conclusion Shenqi Jiangtang Granules combined with Exenatide Injection has clinical effect in treatment of type 2 diabetes mellitus, can reduce blood glucose, reduce insulin resistance, and improve blood glucose fluctuation index, with high safety.

R977

国家自然科学基金资助项目（81400800）