目的 探讨滋肾育胎丸联合黄体酮软胶囊治疗早期先兆流产的临床疗效。方法 选取2019年1月—2020年12月天津中医药大学第一附属医院收治的100例早期先兆流产患者，按照随机数字表法将所有患者分为对照组和治疗组，每组各50例。对照组每晚口服黄体酮软胶囊，200 mg/次，1次/d。治疗组在对照组基础上口服滋肾育胎丸，5 g/次，3次/d。两组患者连续治疗2周。观察两组临床疗效，比较两组治疗前后的症状消失情况、血流动力学指标和激素水平。结果 治疗后，治疗组的总有效率为96.00%，对照组为84.00%，组间比较差异有统计学意义（P<0.05）。治疗后，两组阴道流血、下腹坠胀、腹痛、腰酸消失例数明显降低（P<0.05）；且治疗组阴道流血、下腹坠胀、腹痛、腰酸消失例数降低情况优于对照组，差异有统计学意义（P<0.05）。治疗后，两组的平均血流速度明显升高，阻力指数、搏动指数明显降低（P<0.05）；且治疗组的平均血流速度比对照组高，阻力指数、搏动指数比对照组低（P<0.05）。治疗后，两组的孕酮、β-绒毛膜促性腺激素（β-HCG）水平显著升高（P<0.05）；且治疗组的孕酮、β-HCG水平高于对照组，差异有统计学意义（P<0.05）。结论 滋肾育胎丸联合黄体酮软胶囊治疗早期先兆流产的疗效确切，能减轻临床症状，改善血流动力学水平，且安全性良好。

Objective To investigate the clinical effect of Zishen Yutai Pills combined with Progesterone Soft Capsules in treatment of early threatened abortion. Methods Patients (100 cases) with early threatened abortion in First Teaching Hospital of Tianjin University of Traditional Chinese Medicine from January 2019 to December 2020 were randomly divided into control and treatment groups, and each group had 50 cases. Patients in the control group were po administered with Progesterone Soft Capsules at night, 200 mg/time, once daily. Patients in the treatment group were po administered with Zishen Yutai Pills on the basis of the control group, 5 g/time, three times daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and the disappearance of symptoms, hemodynamic indicators, and hormone levels of two groups were compared. Results After treatment, the total effective rate was 96.00% in the treatment group and 84.00% in the control group, and the difference was statistically significant (P<0.05). After treatment, the number of cases of vaginal bleeding, lower abdominal distension, abdominal pain, and lumbar acid disappearance in two groups was significantly reduced (P<0.05). The number of cases of vaginal bleeding, lower abdominal distension, abdominal pain, and lumbar acid disappearance of the treatment group was better than that of the control group (P<0.05). After treatment, the levels of progesterone and β-HCG in two groups were increased significantly (P<0.05), and the levels of progesterone and β-HCG in the treatment group were higher than those in the control group, and the difference was statistically significant (P<0.05). Conclusion Zishen Yutai Pills combined with Progesterone Soft Capsules is effective in the treatment of early threatened abortion, can reduce the clinical symptoms, improve the level of hemodynamics, with good safety.

R984

天津市科委科研计划项目（2019KJ047）