目的 探讨蒲公英颗粒联合注射用头孢拉定治疗急性乳腺炎的临床疗效。方法 选择2020年2月—2020年9月在河南省中医院治疗的112例急性乳腺炎患者，根据诊治顺序分成对照组（56例）和治疗组（56例）。对照组静脉滴注注射用头孢拉定，1.0 g加入生理盐水100 mL，6 h/次。治疗组在对照组基础上口服蒲公英颗粒，15 g/次，3次/d。两组均治疗1周。观察两组患者临床疗效，比较治疗前后两组患者临床症状改善时间，及血清学指标超敏C反应蛋白（hs-CRP）、白细胞介素-6（IL-6）、降钙素原（PCT）、细胞间黏附分子-1（ICAM-1）和肿瘤坏死因子-α（TNF-α）水平。结果 经治疗，对照组总有效率为85.71%，显著低于治疗组的98.21%（P<0.05）。经治疗，治疗组在乳房肿痛消失时间、退热时间、肿块消失时间、通乳时间上均优于对照组（P<0.05）。经治疗，两组患者血清hs-CRP、IL-6、PCT、ICAM-1、TNF-α水平均显著降低（P<0.05），治疗组下降最明显（P<0.05）。结论 蒲公英颗粒联合注射用头孢拉定治疗急性乳腺炎可有效改善患者临床症状，降低机体炎症反应，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Pugongying Granules combined with cefradine in treatment of acute mastitis. Methods Patients (112 cases) with acute mastitis in Henan Province Hospital of TCM from February 2020 to September 2020 were divided into control (56 cases) and treatment (56 cases) groups based on order of diagnosis and treatment. Patients in the control group were iv administered with Cefradine for injection, 1.0 g added into normal saline 100 mL, 6 h/time. Patients in the treatment group were po administered with Pugongying Granules on the basis of the control group, 15 g/time, three times daily. Patients in two groups were treated for 1 week. After treatment, the clinical efficacy was evaluated, and the disappearance time of clinical symptoms, and the levels of serological indexes hs-CRP, IL-6, PCT, ICAM-1 and TNF-α in two groups before and after treatment were compared. Results After treatment, the effective rate of the control group was 85.71%, which was significantly lower than 98.21% of the treatment group (P<0.05). After treatment, the time of disappearance of breast swelling and pain, antipyretic time, mass disappearance time and breast opening time in the treatment group was superior to that in the control group (P<0.05). After treatment, the serum levels of hs-CRP, IL-6, PCT, ICAM-1 and TNF-α in the two groups decreased significantly (P<0.05), especially in the treatment group (P<0.05). Conclusion Pugongying Granules combined with cefradine in treatment of acute mastitis can effectively improve the clinical symptoms, reduce the inflammatory reaction, which has a certain clinical application value.

R984