[关键词]
[摘要]
目的 探讨脉络宁注射液联合硫酸镁注射液治疗妊娠高血压综合征的临床疗效。方法 选择2018年11月—2020年10月在郑州市妇幼保健院西区就诊的84例妊娠高血压综合征患者,按照随机数字表法将84例患者分为对照组和治疗组,每组各42例。对照组给予硫酸镁注射液,首次剂量10 mL硫酸镁注射液使用5%葡萄糖液稀释至20 mL在5 min内静脉注射,然后给予60 mL硫酸镁注射液加入500 mL的5%葡萄糖液充分稀释,以1~2 g/h静脉滴注,1次/d。治疗组在对照组基础上静脉滴注脉络宁注射液,10 mL加入250 mL的5%葡萄糖液,1次/d。两组患者连续治疗7 d。观察两组的临床疗效,比较两组的血压变化,检测两组治疗前后血清白细胞介素-18(IL-18)、D-二聚体、同型半胱氨酸(Hcy)水平,随访记录两组的不良妊娠结局。结果 治疗后,治疗组患者的总有效率为90.48%,对照组的总有效率为73.81%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者的收缩压和舒张压均显著降低(P<0.05),治疗组的收缩压和舒张压较对照组降低的更明显,差异有统计学意义(P<0.05)。治疗后,两组的IL-18、D-二聚体、Hcy水平明显降低(P<0.05);治疗后,治疗组的IL-18、D-二聚体、Hcy水平低于对照组,差异有统计学意义(P<0.05)。治疗组的产后出血、新生儿窒息、胎盘早剥、早产例数均少于对照组(P<0.05)。结论 脉络宁注射液联合硫酸镁注射液可提高妊娠高血压综合征的疗效,控制血压,纠正血液高凝状态,有助于改善妊娠结局。
[Key word]
[Abstract]
Objective To investigate the clinical effect of Mailuoning Injection combined with Magnesium Sulfate Injection in treatment of pregnancy-induced hypertension syndrome. Methods Patients (84 cases) with pregnancy-induced hypertension syndrome in West District of Women & Infants Hospital of Zhengzhou from November 2018 to October 2020 were randomly divided into control and treatment groups, and each group had 42 cases. Patients in the control group were given Magnesium Sulfate Injection, the first dose of 10 mL magnesium sulfate injection was diluted to 20 mL with 5% glucose solution, and injected intravenously within 5 min, then 60 mL magnesium sulfate injection was given and diluted to 500 mL with 5% glucose solution, the injection was given intravenously at 1 — 2 g/h, once daily. Patients in the treatment group were po administered with Mailuoning Injection on the basis of the control group, 10 mL added into 5% glucose solution 500 mL, once daily. Patients in two groups were treated for 7 d. After treatment, the clinical efficacies were evaluated, the changes of blood pressure of two groups were compared, and the serum levels of IL-18, D-dimer, and Hcy were detected before and after treatment. The adverse pregnancy outcomes of two groups were followed up. Results After treatment, the total effective rate of the treatment group was 90.48%, the control group was 73.81%, and the difference was statistically significant (P<0.05). After treatment, the systolic pressure and diastolic pressure of two groups were significantly decreased (P<0.05). And the blood pressure of the treatment group was more significantly lower than that of the control group, the difference was statistically significant (P<0.05). After treatment, the levels of IL-18, D-dimer, and Hcy in two groups were significantly decreased (P<0.05). After treatment, the levels of IL-18, D-dimer, and Hcy in the treatment group were lower than those in the control group, and the difference was statistically significant (P<0.05). The postpartum hemorrhage, neonatal asphyxia, placental abruption and premature birth in the treatment group were lower than those in the control group (P<0.05). Conclusion Mailuoning Injection combined with Magnesium Sulfate Injection can improve the curative effect of pregnancy-induced hypertension syndrome, control blood pressure, correct blood hypercoagulability, and help to improve pregnancy outcome.
[中图分类号]
R984
[基金项目]
河南省医学科技攻关计划省部共建项目(SB201901046)