目的 探讨五淋化石丸联合黄酮哌酯治疗慢性非细菌性前列腺炎的临床疗效。方法 选取2018年1月—2020年1月在驻马店市中心医院泌尿一科住院治疗的134例慢性非细菌性前列腺炎患者，随机分成对照组（n=67）和治疗组（n=67）。对照组口服盐酸黄酮哌脂片，0.2 g/次，3次/d。治疗组在对照组的基础上口服五淋化石丸，5丸/次，3次/d。两组均同时治疗7 d。观察两组的临床疗效，比较两组治疗前后NIH-CPSI评分和血清炎性因子的变化情况。结果 治疗后，治疗组总有效率97.01%显著高于对照组的74.63%（P<0.05）。治疗后，两组疼痛症状评分、排尿症状评分、生活质量评分均显著降低（P<0.05）；治疗后，治疗组NIH-CPSI评分显著低于对照组（P<0.05）。治疗后，两组患者白细胞介素4（IL-4）、白细胞介素8（IL-8）、肿瘤坏死因子α（TNF-α）、干扰素γ（IFN-γ）水平均显著降低（P<0.05）；治疗后，治疗组血清炎性因子水平低于对照组（P<0.05）。结论 五淋化石丸联合黄酮哌酯治疗慢性非细菌性前列腺炎临床疗效显著，能有效改善尿频、尿急、尿痛等症状，降低炎症因子的水平，值得临床借鉴与参考。

Objective To investigate the therapeutic effect of Wulin Huashi Pills combined with flavonolate in treatment of chronic abacterial prostatitis. Methods A total of 134 patients with chronic abacterial prostatitis who were hospitalized in the Department of Urology of Zhumadian Central Hospital from January 2018 to January 2020 were selected and randomly divided into control group (n=67) and treatment group (n=67). Patients in the control group were po administered with Flavoxate Hydrochloride Tablets, 0.2 g/time, three times daily. Patients in the treatment group were po administered with Wulin Huashi Pills on the basis of the control group, 5 pills/time, three times daily. Patients in two groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, and the changes of NIH-CPSI scores and serum inflammatory factors were compared between the two groups before and after treatment. Results After treatment, the total effective rate of 97.01% in treatment group was significantly higher than that of 74.63% in control group (P<0.05). After treatment, pain symptom score, urination symptom score and quality of life score were significantly decreased in both groups (P<0.05). After treatment, the NIH-CPSI score in the treatment group was significantly lower than that in the control group (P<0.05). After treatment, the levels of interleukin 4 (IL-4), interleukin 8 (IL-8), tumor necrosis factor α (TNF-α), and interferon γ (IFN-γ) in two groups were significantly decreased (P<0.05). After treatment, the level of serum inflammatory factors in treatment group was lower than that in control group (P<0.05). Conclusion Wulin Huashi Pills combined with flavonolate has significant clinical effect in treatment of chronic abacterial prostatitis, and can effectively improve the symptoms of frequent urination, urgent urination and dysphoria, and reduce the level of inflammatory factors, which is worth clinical reference and reference.

R983

河南省科技攻关项目（201502161）