[关键词]
[摘要]
目的 探讨注射用丹参多酚酸盐联合苯溴马隆胶囊治疗痛风性关节炎的临床疗效。方法 选取2019年7月—2020年9月在河南省洛阳正骨医院就诊的92例痛风性关节炎患者,按照随机数字表法分为对照组和治疗组,每组各有46例。对照组口服苯溴马隆胶囊,50 mg/次,1次/d。治疗组在对照组基础上静脉滴注注射用丹参多酚酸盐,200 mg/次,1次/d。两组患者连续治疗4周。观察两组的临床疗效,比较两组的疼痛消失时间、红肿消失时间,检测两组血清中白细胞介素-8(IL-8)、白细胞介素-1β(IL-1β)、转化生长因子-β1(TGF-β1)、血尿酸、血沉水平。结果 治疗后,治疗组的总有效率为93.48%,对照组的总有效率为78.26%,两组对比有明显差异(P<0.05)。治疗后,两组患者的视觉模拟评分法(VAS)评分显著降低(P<0.05);治疗组VAS评分降低更明显(P<0.05)。治疗后,治疗组的疼痛消失时间、红肿消失时间短于对照组,差异有统计学意义(P<0.05)。治疗后,两组的IL-8、IL-1β、血尿酸、血沉显著降低,TGF-β1显著升高(P<0.05);治疗后,治疗组的IL-8、IL-1β、血尿酸、血沉低于对照组,TGF-β1高于对照组(P<0.05)。结论 注射用丹参多酚酸盐联合苯溴马隆胶囊可提高痛风性关节炎的临床疗效,减轻疼痛程度,降低炎症因子水平。
[Key word]
[Abstract]
Objective To investigate the clinical efficacy of Salvianolic Acids for injection combined with Benzbromarone Capsules in treatment of gouty arthritis. Methods Patients (92 cases) with gouty arthritis in Luoyang Orthopedic-Traumatological Hospital of Henan Province from July 2019 to September 2020 were randomly divided into control and treatment groups, and each group had 46 cases. Patients in the control group were po administered with Benzbromarone Capsules, 50 mg/time, once daily. Patients in the treatment group were po administered with Salvianolic Acids for injection on the basis of the control group, 200 mg/time, once daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, the disappearance time of pain and swelling in two groups were compared, and the levels of IL-8, IL-1β, TGF-β1, serum uric acid, and erythrocyte sedimentation rate in two groups were detected. Results After treatment, the total effective rate of the treatment group was 93.48%, while that of the control group was 78.26%, and there was significant difference between two groups (P<0.05). After treatment, the VAS score of two groups were significantly decreased (P<0.05), and the VAS score of the treatment group was significantly lower than that of the control group (P<0.05). After treatment, the pain disappearance times and swelling disappearance time of the treatment group were shorter than those of the control group, and the difference was statistically significant (P<0.05). After treatment, IL-8, IL-1β, serum uric acid, and erythrocyte sedimentation rate of two groups were significantly decreased, while TGF-β1 of two groups was significantly increased (P<0.05). After treatment, IL-8, IL-1β, serum uric acid, and erythrocyte sedimentation rate of the treatment group were lower than those of the control group, while TGF-β1 of the treatment group was higher than that of the control group (P<0.05). Conclusion Salvianolic Acids for injection combined with Benzbromarone Capsules can improve the curative effect of gouty arthritis, reduce the degree of pain, and reduce the level of inflammatory factors.
[中图分类号]
R98
[基金项目]
河南省中医药科学研究专项(2018ZY2019)