目的 观察甘桔冰梅片联合布地奈德吸入气雾剂雾化吸入治疗慢性咽炎的临床疗效。方法 选取2019年1月—2019年12月新乡市第一人民医院收治的100例慢性咽炎患者，参照随机数字表法将患者分为对照组和治疗组，每组各50例。对照组雾化吸入布地奈德吸入气雾剂，0.5 mg/次，3次/d。治疗组在对照组治疗的基础上口服甘桔冰梅片，2片/次，3次/d。两组均以7 d为1个疗程，持续治疗3个疗程。观察两组的临床疗效，比较两组症状消失时间、血清炎症因子水平。结果 治疗后，对照组的总有效率为80.00%，治疗组的总有效率为94.00%，治疗组的临床总有效率高于对照组（P<0.05）。治疗后，治疗组咽喉干痒、黏膜充血、声音嘶哑和咽喉疼痛消失时间均短于对照组（P<0.05）。治疗后，两组血清白细胞介素-6（IL-6）和超敏C反应蛋白（hs-CRP）水平较治疗前降低（P<0.05），治疗后治疗组血清IL-6和hs-CRP水平较对照组低（P<0.05）。结论 甘桔冰梅片联合布地奈德吸入气雾剂雾化吸入治疗慢性咽炎可促进临床症状改善，安全有效，其主要作用机制可能与降低炎症因子水平有关。

Objective To observe the clinical effect of Ganju Bingmei Tablets combined with Budesonide Inhalation Aerosol in treatment of chronic pharyngitis. Methods Patients (100 cases) with chronic pharyngitis in Xinxiang First People’s Hospital from January 2019 to December 2019 were randomly divided into control and treatment groups, and each group had 50 cases. Patients in the control group were atomization inhalation with Budesonide Inhalation Aerosol, 0.5 mg/time, three times daily. Patients in the treatment group were po administered with Ganju Bingmei Tablets on the basis of the control group, 2 tablets/time, three times daily. 7 days as A course of treatment, two groups of patients continued treatment for 3 courses. After treatment, the clinical efficacies were evaluated, and the levels of serum inflammatory factors and the disappearance time of symptoms were compared between two groups. Results After treatment, the total effective rate of the control group and the treatment group were 80.00% and 94.00%, and the total clinical effective rate of the treatment group was higher than that of the control group (P<0.05). After treatment, the disappearance time of dry throat itching, mucosal congestion, hoarseness and sore throat in the treatment group were shorter than those in the control group (P<0.05). After treatment, the serum levels of IL-6 and hs-CRP in two groups were lower than those before treatment (P<0.05), and the serum levels of IL-6 and hs-CRP in the treatment group were lower than those in the control group after treatment (P<0.05). Conclusion Ganju Bingmei Tablets combined with Budesonide Inhalation Aerosol in treatment of chronic pharyngitis can promote the improvement of clinical symptoms, with good safety, which main mechanism may be related to reduction of inflammatory factors.

R974

河南省科技发展计划项目（18210211463）