目的 探讨柴芩清宁胶囊联合利巴韦林治疗急性上呼吸道感染的临床疗效。方法 选取2019年7月—2020年7月在中国人民武装警察部队特色医学中心进行治疗的98例急性上呼吸道感染患者为研究对象，根据用药的差别分为对照组（49例）和治疗组（49例）。对照组静脉滴注利巴韦林注射液，0.5 g/次，2次/d，同0.9%氯化钠注射液100 mL配伍。治疗组在对照组基础上口服柴芩清宁胶囊，3粒/次，3次/d。两组均治疗7 d。观察两组的临床疗效，比较两组临床症状消失时间和血清因子水平的变化情况。结果 经治疗，治疗组的总有效率97.96%，显著高于对照组的83.67%（P<0.05）。经治疗，治疗组体温恢复正常时间、咽痛消失时间、咳嗽消失时间、鼻卡他/鼻塞消失时间均显著短于对照组（P<0.05）。经治疗，两组血清超敏C反应蛋白（hs-CRP）、淀粉样蛋白A（SAA）、半胱氨酰白三烯（CYSLTS）、白细胞介素-17（IL-17）、巨噬细胞迁移抑制因子（MIF）水平均显著降低（P<0.05）；治疗后，治疗组患者这些血清学指标显著低于对照组（P<0.05）。结论 柴芩清宁胶囊联合利巴韦林治疗急性上呼吸道感染患者不仅可促进临床症状恢复，还可显著降低机体炎症因子水平，具有很好的临床价值。

Objective To investigate the clinical efficacy of Chaiqin Qingning Capsules combined with ribavirin in treatment of acute upper respiratory tract infection. Methods Patients (98 cases) with acute upper respiratory tract infection in Characteristic Medical Center of Chinese People's Armed Police Force from July 2019 to July 2020 were divided into control and treatment groups according to different medication regimens, and each group had 49 cases. Patients in the control group were iv administered with Ribavirin Injection, 0.5 g/time, twice daily, with 0.9% sodium chloride injection 100 mL. Patients in the treatment group were po administered with Chaiqin Qingning Capsules on the basis of the control group, 3 grains/time, three times daily. Patients in tw o groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, disappearance time of clinical symptom and the change of serum factors between two groups were compared. Results After treatment, the total effective rate of treatment group was 97.96%, which was significantly higher than that of control group (83.67%, P<0.05). After treatment, the recovery time of body temperature, disappearance time of pharyngeal pain, disappearance time of cough and disappearance time of nasal catal/nasal obstruction in the treatment group were significantly shorter than those in the control group (P<0.05). After treatment, the serum levels of hypersensitive C-reactive protein (hs-CRP), amyloid A (SAA), CYSLTS, interleukin-17 (IL-17) and macrophage migration inhibitory factor (MIF) were significantly decreased in both groups (P<0.05). After treatment, these serological indexes in treatment group were significantly lower than those in control group (P<0.05). Conclusion Chaiqin Qingning Capsules combined with ribavirin in treatment of acute upper respiratory tract infection can not only promote the recovery of clinical symptoms, but also significantly reduce the level of inflammatory factors in the body, which has a good clinical value.

R974

天津市科技计划项目（17JCTPJC63400）