随着抗菌药物使用的增加，肠杆菌科细菌耐药的情况越发严重，可供选择的抗菌药物将越来越少。天然药物因其作用范围广、毒副作用较小在抗感染研究中备受关注，而天然药物单体即是其发挥药理学作用的物质基础。就近年来天然药物单体对肠杆菌科细菌的作用及其机制进行综述，为抗菌药物的筛选和开发提供参考。

With the increase of antimicrobial drugs use, the resistance of Enterobacteriaceae is becoming more and more serious, and the available antimicrobial drugs will be less and less. Due to its wide range of action, natural drugs have little toxic side effects. Nowadays, it has attracted much attention in anti-infection research, and natural drug active component is the material basis for its pharmacological action. In this paper, the effect and mechanism of natural drug active components on Enterobacteriaceae in recent years were reviewed, so as to provide reference for the screening and development of antibacterial drugs.

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国家自然科学基金面上项目（81670637）；广州市基础研究计划项目（202002030419）；广州市加速康复腹部外科重点实验室（201905010004）