目的 探讨克霉唑阴道栓联合氟康唑治疗霉菌性阴道炎的临床疗效及安全性。方法 ：选择2019年3月-2020年3月收治的霉菌性阴道炎患者108例，随机分为对照组（54例）和治疗组（54例）。对照组口服氟康唑胶囊，首剂量0.4 g/次，次日0.2 g/次，1次/d。治疗组患者在对照组的基础上睡前阴道深处给予克霉唑阴道栓，月经后开始治疗，1次/d。两组患者连续治疗21 d。观察两组患者临床疗效，同时比较治疗前后两组患者临床症状改善情况、复发率和生存质量。结果 ：治疗后，对照组和治疗临床有效率为83.33%和96.30%，两组比较差异有统计学意义（P<0.05）。治疗后，治疗组腰腹疼痛、尿频尿痛和外阴瘙痒红肿消失时间及白带恢复正常时间明显早于对照组（P<0.05）。治疗后，对照组复发率高于治疗组（P<0.05）。治疗后，治疗组精神状态、情感状态、社会功能和生理机能评分明显好于对照组（P<0.05）。结论 克霉唑阴道栓联合氟康唑治疗霉菌性阴道炎效果显著，提高生存质量，改善患者临床症状和降低临床复发率，具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy and safety of Clotriazole Vaginal Suppository combined with fluconazole in treatment of mycotic vaginitis. Methods Patients (108 cases) with mycotic vaginitis in Central Hospital of Shangqiu from March 2019 to March 2020 were randomly divided into control (54 cases) and treatment (54 cases) groups. Patients in the control group were po administered with Fluconazole Capsules, the initial dose was 0.4 g/time, then 0.2 g/time for the next day. Patients in the treatment group were deep vagina given administered with Clotriazole Vaginal Suppository on the basis of the control group after menstruation, once daily. Patients in two groups were treated for 21 d. After treatment, the clinical efficacy was evaluated, and the improvement of clinical symptom, the recurrence rate, and the survival quality in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 83.33% and 96.30% respectively, and there were differences between two groups (P<0.05). After treatment, the disappearance time of waist and abdomen pain, frequent micturition, pruritus and swelling of vulva and the recovery time of leucorrhea in the treatment group were significantly earlier than those in the control group (P<0.05). After treatment, the recurrence rate of the control group was higher than that of the treatment group (P<0.05). After treatment, the mental state, emotional state, social function and physiological function of the treatment group were significantly better than those of the control group (P<0.05). Conclusion The clinical effect of Clotriazole Vaginal Suppository combined with fluconazole in treatment of mycotic vaginitis is remarkable, which can improve the life quality, improve the clinical symptoms and reduce the recurrence rate, and has a certain clinical application value.

R984