[关键词]
[摘要]
目的 探讨玉泉丸联合达格列净片治疗2型糖尿病的临床疗效。方法 选取2016年9月-2019年12月河南中医药大学第一附属医院收治的98例2型糖尿病患者,将所有患者随机分为对照组和治疗组,每组各49例。对照组早餐前口服达格列净片,5~10 mg/次,1次/d。治疗组在对照组基础上饭后服用玉泉丸,6 g/次,4次/d。两组患者均连续治疗3个月。观察两组的临床疗效,比较两组的血糖指标、胰岛素指标、炎症因子。结果 治疗后,治疗组的总有效率(95.92%)较对照组(79.59%)高(P<0.05)。治疗后,两组白细胞介素-6(IL-6)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)水平较治疗前降低(P<0.05);且治疗组炎症因子水平低于对照组(P<0.05)。治疗后,两组患者空腹血糖(FPG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)较治疗前降低(P<0.05);且治疗组血糖指标低于对照组(P<0.05)。治疗后,两组胰岛素抵抗指数(HOMA-IR)较治疗前降低,胰岛素(FINS)、胰岛β细胞功能指数(HOMA-β)较治疗前升高(P<0.05);且治疗组HOMA-IR低于对照组,FINS、HOMA-β高于对照组(P<0.05)。结论 玉泉丸联合达格列净片治疗2型糖尿病可改善患者血糖及胰岛素分泌,减轻炎症反应,且安全较好。
[Key word]
[Abstract]
Objective To investigate the clinical effect of Yuquan Pills combined with Dapagliflozin Tablets in treatment of type 2 diabetes mellitus. Methods Patients (98 cases) with type 2 diabetes mellitus in the First Affiliated Hospital of Henan University of CM from September 2016 to December 2019 were randomly divided into control and treatment groups, and each group had 49 cases. Patients in the control group were po administered with Dapagliflozin Tablets, 5-10 mg/time, once daily. Patients in the treatment group were po administered with Yuquan Pills on the basis of the control group, 6 g/time, four times daily. Patients in two groups were treated for 3 months. After treatment, the clinical efficacies were evaluated, and blood glucose index, insulin index, and inflammatory factors in two groups were compared. Results After treatment, the total effective rate of the treatment group (95.92%) was higher than that of the control group (79.59%) (P<0.05). After treatment, the levels of IL-6, CRP, and TNF-α in the two groups were lower than those before treatment (P<0.05), and the levels of inflammatory factors in the treatment group were lower than those in the control group (P<0.05). After treatment, the FPG, 2 h PG, and HbA1c of the two groups were lower than those before treatment (P<0.05), and the blood glucose index of the treatment group was lower than that of the control group (P<0.05). After treatment, the HOMA-IR of two groups were decreased, but the FINS and HOMA-β of two groups were increased (P<0.05). After treatment, the HOMA-IR of the treatment group was lower than that of the control group, but the FINS and HOMA-β of the treatment group were higher than that of the control group (P<0.05). Conclusion Yuquan Pills combined with Dapagliflozin Tablets in treatment of type 2 diabetes mellitus can improve blood glucose and insulin secretion, and reduce inflammatory reaction with good safety.
[中图分类号]
R977
[基金项目]
河南省中医药科学研究专项课题(2019 JDZX2105)