目的 探讨黄柏胶囊联合异维A酸红霉素凝胶治疗轻中度痤疮的临床疗效。方法 选择2018年9月-2020年2月在郑州市第七人民医院治疗的轻中度痤疮患者127例，随机分为对照组（63例）和治疗组（64例）。对照组外涂异维A酸红霉素凝胶，1~2次/d。治疗组在对照组基础上口服黄柏胶囊，3粒/次，3次/d。两组患者治疗1个月。观察两组患者临床疗效，同时比较治疗前后两组患者皮损形态、类型、数量和皮肤生理功能情况。结果 治疗后，对照组临床有效率为76.19%，显著低于治疗组的90.63%，两组比较差异有统计学意义（P<0.05）。治疗后，两组患者皮损形态、类型、数量评分显著降低（P<0.05），且治疗组明显低于对照组（P<0.05）。治疗后，两组患者表皮含水量和表皮油脂含量均明显升高（P<0.05），而经皮水分丢失（TEWL）水平明显降低（P<0.05），且治疗组改善效果明显比对照组好（P<0.05）。结论 黄柏胶囊联合异维A酸红霉素凝胶治疗轻中度痤疮，可明显改善患者皮损、色素沉着等临床症状，增强皮肤生理功能，临床疗效好，安全可靠。

Objective To investigate the clinical effect of Huangbai Capsules combined with Isotretinoin Erythromycin Gel in treatment of mild acne. Methods Patients (127 cases) with mild acne in the Seventh People's Hospital of Zhengzhou from September 2018 to February 2020 were randomly divided into control (63 cases) and treatment (64 cases) groups. Patients in the control group were administered with Isotretinoin Erythromycin Gel, 1-2 times daily. Patients in the treatment group were po administered with Huangbai Capsules on the basis of the control group, 3 grains/time, three times daily. Patients in two groups were treated for 1 month. After treatment, the clinical efficacy was evaluated, and the improvement of skin lesion shape, type and quantity and skin physiological function in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 76.19%, which was significantly lower than 90.63% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the scores of skin lesion shape, type, and quantity in two groups were significantly decreased (P<0.05), and which in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the content of epidermal water and epidermal oil in two groups was significantly increased (P<0.05), but the TEWL levels were significantly decreased (P<0.05), and the skin physiological function in the treatment group was significantly better than those in the control group (P<0.05). Conclusion Huangbai Capsules combined with Isotretinoin Erythromycin Gel in treatment of mild acne can significantly improve the clinical symptoms of skin lesions, pigmentation, enhance the physiological function of skin, and has good clinical efficacy, safety and reliability.

R986

河南省医学科技攻关计划（102300410246）