目的 探讨清肝降压胶囊联合他氟前列素滴眼液治疗开角型青光眼的临床疗效。方法 选取2019年1月-2020年8月洛阳市第三人民医院收治的94例开角型青光眼患者作为研究对象，按照随机数字表法将94例患者分为对照组和治疗组，每组各47例。对照组给予他氟前列素滴眼液，1滴/次，1次/d。治疗组在对照组基础上口服清肝降压胶囊，3粒/次，3次/d。两组患者连续治疗4周。观察两组患者的临床疗效，比较两组患者治疗前后的眼压、缺损值（MD）、视敏度值（MS）、平均血流速度（V_m）、搏动指数（PI）、收缩期血流峰值速度（PSV）。结果 治疗后，治疗组患者的总有效率为93.62%，对照组的总有效率为78.72%，组间比较差异有统计学意义（P<0.05）。治疗后，两组的眼压、MD明显降低，MS明显升高，差异有统计学意义（P<0.05）；治疗后，治疗组的眼压、MD低于对照组，MS高于对照组，差异有统计学意义（P<0.05）。治疗后，两组的V_m、PSV明显升高，PI明显降低，差异有统计学意义（P<0.05）；治疗后，治疗组的V_m、PSV高于对照组，PI低于对照组，差异有统计学意义（P<0.05）。结论 清肝降压胶囊联合他氟前列素滴眼液可提高开角型青光眼的疗效，降低眼压，改善患者的临床症状和血流动力学水平，且安全性良好。

Objective To investigate the clinical effect of Qinggan Jiangya Capsules combined with Tafluprost Eye Drops in treatment of open angle glaucoma. Methods Patients (94 cases) with open angle glaucoma in Luoyang Third People's Hospital from January 2019 to August 2020 were randomly divided into control and treatment groups, and each group had 47 cases. Patients in the control group were given Tafluprost Eye Drops, 1 drop/time, once daily. Patients in the treatment group were po administered with Qinggan Jiangya Capsules on the basis of the control group, 3 grains/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and intraocular pressure, mean defect of visual field (MD), mean of sensitivity (MS), mean flow velocity (V_m), pulsatility index (PI), and peak systolic velocity (PSV) in two groups were compared. Results After treatment, the total effective rates in the treatment group and the control group were 93.62% and 78.72%, and the difference between the two groups was statistically significant (P<0.05). After treatment, the intraocular pressure and MD of the two groups were significantly decreased, but the MS of the two groups was significantly increased, and the difference was statistically significant (P<0.05). After treatment, the intraocular pressure and MD of the treatment group were lower than those of the control group, but the MS of the treatment group was higher than those of the control group, and the difference was statistically significant (P<0.05). After treatment, the VM and PSV of the two groups were significantly increased, but the PI of the two groups was significantly decreased, and the difference was statistically significant (P<0.05). After treatment, the VM and PSV of the treatment group were higher than those in the control group, but the PI of the treatment group was lower than that of the control group, and the difference was statistically significant (P<0.05). Conclusion Qinggan Jiangya Capsules combined with Tafluprost Eye Drops can improve the curative effect of open angle glaucoma, reduce intraocular pressure, and improve the clinical symptoms and hemodynamic level, with good safety.

R988.1

河南省医学科技攻关计划联合共建项目（LHGJ20190570）