目的 探讨贞芪益肾颗粒联合来氟米特片治疗慢性肾小球肾炎的临床疗效。方法 选取2019年3月-2020年9月在漯河市中心医院就诊的110例慢性肾小球肾炎患者作为本研究对象，将全部患者按照随机数字表法分为对照组和治疗组，每组各55例。对照组口服来氟米特片，20 mg/次，1次/d。治疗组在对照组基础上温水冲服贞芪益肾颗粒，9 g/次，1次/d。两组患者连续治疗8周。观察两组的疗效，比较两组的肾功能指标和血清炎性因子指标。结果 治疗后，治疗组的总有效率为92.75%，对照组的总有效率为78.18%，组间差异有统计学意义（P<0.05）。治疗后，两组的肌酐（Scr）、尿素氮（BUN）、胱抑素C（Cys-C）、24 h尿蛋白定量水平均显著降低，差异有统计学意义（P<0.05）；且治疗组肾功能指标降低的更明显，差异有统计学意义（P<0.05）。治疗后，两组的超敏C反应蛋白（hs-CRP）、白细胞介素-1β（IL-1β）、单核细胞趋化蛋白-1（MCP-1）、白细胞介素-17（IL-17）水平均明显降低（P<0.05）；治疗后，治疗组的hs-CRP、IL-1β、MCP-1、IL-17水平低于对照组，差异有统计学意义（P<0.05）。结论 贞芪益肾颗粒联合来氟米特片可提高慢性肾小球肾炎的疗效，进一步减轻炎症反应，改善肾功能，且安全性良好。

Objective To investigate the clinical effect of Zhenqiyishen Granules combined with Leflunomide Tablets in treatment of chronic glomerulonephritis. Methods Patients (110 cases) with chronic glomerulonephritis in Luohe Central Hospital from March 2019 to September 2015 were randomly divided into control and treatment groups, and each group had 55 cases. Patients in the control group were po administered with Leflunomide Tablets, 20 mg/time, once daily. Patients in the treatment group were po administered with Zhenqiyishen Granules on the basis of the control group, 9 g/time, once daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacies were evaluated, and renal function index and serum inflammatory factor factors in two groups were compared. Results After treatment, the total effective rates were 92.75% and 78.18% in the treatment group and control group, and the difference was statistically significant (P<0.05). After treatment, the levels of SCR, BUN, Cys-C, and 24 h urinary protein in two groups were significantly decreased, and the difference was statistically significant (P<0.05). And these indexes in the treatment group were significantly lower than those in the control group, and the difference was statistically significant (P<0.05). After treatment, the levels of hs-CRP, IL-1β, MCP-1, and IL-17 in two groups were significantly decreased (P<0.05). After treatment, the levels of hs-CRP, IL-1β, MCP-1, and IL-17 in the treatment group were lower than those in the control group, and the difference was statistically significant (P<0.05). Conclusion Zhenqiyishen Granules combined with Leflunomide Tablets can improve the curative effect of chronic glomerulonephritis, further reduce inflammatory reaction, and improve renal function, with good safety.

R983

河南省中医药科学研究专项课题（2018ZY2030）