[关键词]
[摘要]
目的 探讨参泽舒肝胶囊联合谷胱甘肽治疗非酒精性脂肪性肝炎的临床疗效。方法 以2019年3月-2020年3月在郑州市第六人民医院进行诊治的98例非酒精性脂肪性肝炎患者为研究对象,根据就诊顺序分成对照组(49例)和治疗组(49例)。对照组口服谷胱甘肽片,0.4 g/次,3次/d;治疗组在对照组治疗基础上口服参泽舒肝胶囊,1.5 g/次,3次/d。两组均治疗12周。观察两组的临床疗效,比较两组治疗前后肝功能指标、血脂指标和血清学炎性因子的变化情况。结果 经治疗,对照组总有效率为81.63%,显著低于治疗组(95.92%,P<0.05)。经治疗,两组丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、γ-谷氨酰转肽酶(γ-GT)、总胆红素(TBIL)水平均较治疗前显著下降(P<0.05);治疗后,治疗组肝功能指标显著低于对照组(P<0.05)。经治疗,两组总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)水平均显著下降,但高密度脂蛋白胆固醇(HDL-C)均升高(P<0.05);且治疗后,治疗组TC、TG、LDL-C水平均低于对照组,而HDL-C高于对照组(P<0.05)。经治疗,两组丝氨酸蛋白酶抑制剂(Vaspin)、成纤维细胞生长因子-21(FGF21)、纤溶酶原激活物抑制剂-1(PAI-1)水平均显著下降,而可溶性白细胞分化抗原163(sCD163)、脂联素(APN)均显著上升(P<0.05);且治疗后,治疗组Vaspin、FGF21、PAI-1水平低于对照组,而sCD163、APN高于对照组(P<0.05)。结论 参泽舒肝胶囊联合谷胱甘肽治疗非酒精性脂肪性肝炎具有较好的疗效,可有效改善患者肝功能,调节机体血脂水平,改善血清细胞因子水平,有着良好的临床应用价值。
[Key word]
[Abstract]
Objective To investigate the clinical efficacy of Shenze Shugan Capsules combined with glutathione in treatment of nonalcoholic steatohepatitis. Methods A total of 98 patients with non-alcoholic steatohepatitis who received diagnosis and treatment in Zhengzhou Sixth People's Hospital from March 2019 to March 2020 were selected as the research subjects. According to the order of treatment, they were divided into control group (49 cases) and treatment group (49 cases). Patients in the control group were po administered with Glutathione Tablets, 0.4 g/time, three times daily. Patients in the treatment group were po administered with Shenze Shugan Capsules on the basis of the control group, 1.5 g/time, three times daily. Both groups were treated for 12 weeks. The clinical efficacy of the two groups was observed, and the changes of liver function indexes, blood lipid indexes and serological inflammatory factors were compared before and after treatment. Results After treatment, the total effective rate of the control group was 81.63%, significantly lower than that of the treatment group (95.92%, P<0.05). After treatment, the levels of ALT, AST, γ-GT and TBIL in two groups were significantly decreased compared with before treatment (P<0.05). After treatment, liver function indexes in treatment group were significantly lower than those in control group (P<0.05). After treatment, the levels of TC, TG and LDL-C in two groups were significantly decreased, but the levels of HDL-C were increased (P<0.05). After treatment, the levels of TC, TG and LDL-C in the treatment group were lower than those in the control group, while HDL-C was higher than those in the control group (P<0.05). After treatment, the levels of Vaspin, FGF21 and PAI-1 in two groups were significantly decreased, while the levels of sCD163 and APN were significantly increased (P<0.05). After treatment, the levels of Vaspin, FGF21 and PAI-1 in the treatment group were lower than those in the control group, while sCD163 and APN were higher than those in the control group (P<0.05). Conclusion Shenze Shugan Capsules combined with glutathione has good curative effect in treatment of non-alcoholic steatohepatitis, and can effectively improve the patient's liver function, also can regulate the body lipid level, improve the serum cytokine level, which has a good clinical application value.
[中图分类号]
R975
[基金项目]
国家科技重大专项课题(2018ZX09201016)