[关键词]
[摘要]
目的 探讨肠炎宁糖浆联合奥替溴铵片治疗肠易激综合征的临床疗效。方法 选取2019年4月-2020年8月河南医学高等专科学校附属医院收治的92例肠易激综合征患者为研究对象,根据随机数字表法将92例分为对照组和治疗组,每组各46例。对照组口服奥替溴铵片,40 mg/次,3次/d。治疗组在对照组基础上口服肠炎宁糖浆,10 mL/次,3次/d。两组患者连续治疗4周。观察两组的临床疗效,比较两组的腹痛、腹胀、腹泻消失时间,肠易激综合征的特征指数生活质量量表(IBS-QOL)评分和血清中白细胞介素-6(IL-6)、白细胞介素-18(IL-18)、神经肽Y(NRY)、血管活性肠肽(VIP)、胆囊收缩素(CCK)、胃动素(MTL)水平。结果 治疗后,治疗组患者的总有效率为93.48%,对照组的总有效率为78.26%,组间有明显差异(P<0.05)。治疗后,治疗组患者腹痛、腹胀、腹泻消失时间均比对照组短(P<0.05)。治疗后,两组患者的IBS-QOL评分明显升高,差异有统计学意义(P<0.05);且治疗组患者IBS-QOL评分升高的更明显,差异有统计学意义(P<0.05)。治疗后,两组的IL-6、IL-18水平明显降低,NRY水平明显升高(P<0.05);且治疗后治疗组的IL-6、IL-18水平低于对照组,NRY水平高于对照组(P<0.05)。治疗后,两组的CCK水平明显升高,VIP、MTL水平明显降低(P<0.05);且治疗后治疗组的CCK水平比对照组高,VIP、MTL水平低于对照组,差异有统计学意义(P<0.05)。结论 肠炎宁糖浆联合奥替溴铵片可提高肠易激综合征的临床疗效,改善临床症状,增强患者的生活质量,减轻炎症反应,调节胃肠激素,安全性良好。
[Key word]
[Abstract]
Objective To investigate the clinical effect of Changyanning Syrup combined with Otilonium Bromide Tablets in treatment of irritable bowel syndrome. Methods Patients (92 cases) with irritable bowel syndrome in Henan Medical College Hospital Workers from April 2019 to August 2020 were randomly divided into control and treatment groups, and each group had 46 cases. Patients in the control group were po administered with Otilonium Bromide Tablets, 40 mg/time, three times daily. Patients in the treatment group were po administered with Changyanning Syrup on the basis of the control group, 10 mL/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and the disappearance time of abdominal pain, abdominal distension, and diarrhea, the IBS-QOL scores, and the levels of IL-6, NRY, IL-18, VIP, CCK, and MTL in two groups were compared. Results After treatment, the total effective rates in the treatment group and control group were 93.48% and 78.26%, with significant difference between two groups (P<0.05). After treatment, the disappearance times of abdominal pain, abdominal distension, and diarrhea in the treatment group were shorter than those in the control group (P<0.05). After treatment, the IBS-QOL scores of two groups were significantly increased, and the difference was statistically significant (P<0.05). And the IBS-QOL scores of the treatment group were higher than those of the control group, and the difference was statistically significant (P<0.05). After treatment, the levels of IL-6 and IL-18 in two groups were significantly decreased, but the level of NRY in two groups was significantly increased (P<0.05). After treatment, the levels of IL-6 and IL-18 in the treatment group were lower than those in the control group, but the level of NRY in the treatment group was higher than that in the control group (P<0.05). After treatment, the levels of CCK in two groups were significantly increased, but the levels of VIP and MTL were significantly decreased (P<0.05). After treatment, the level of CCK in the treatment group was higher than that in the control group, while the levels of VIP and MTL in the treatment group were lower than those in the control group, and the difference was statistically significant (P<0.05). Conclusion Changyanning Syrup combined with Otilonium Bromide Tablets can improve the clinical efficacy of irritable bowel syndrome, improve the clinical symptoms, enhance the quality of life of patients, reduce inflammatory reaction, regulate gastrointestinal hormones, with good safety.
[中图分类号]
R975
[基金项目]
河南省医学科技攻关计划联合共建项目(2018020853)