在以聚乳酸–乙醇酸共聚物（PLGA）为辅料的药物缓控释制剂中，药物的释放行为主要取决于PLGA聚合物的降解行为。PLGA的降解行为受骨架结构、环境因素和剂型因素等影响。对PLGA的降解机制进行剖析，并综述影响PLGA降解行为的相关因素，包括PLGA的单体聚乳酸与聚乙醇酸的比例、相对分子质量、pH值、结晶度、温度、药物的类型和基质包封药物后的剂型等，同时论述了其对缓控释制剂药物释放行为的影响。

In the drug sustained and controlled release preparations with polylactic acid-glycolic acid copolymer (PLGA) as excipients, the drug release behavior mainly depends on the degradation behavior of PLGA polymer. The degradation behavior of PLGA is affected by the skeleton structure, environmental factors and dosage form factors. In this paper, the degradation mechanism of PLGA was analyzed, and the related factors affecting the degradation behavior of PLGA were systematically reviewed, including the ratio of PLGA monomer polylactic acid and polyglycolic acid, relative molecular weight, pH value, crystallinity, temperature, drug type and dosage form after drug encapsulated by matrix, and its effect on the drug release behavior of sustained and controlled release preparations was discussed.

R944