目的 观察少腹逐瘀颗粒联合布洛芬缓释胶囊治疗原发性痛经的临床疗效。方法 选取2018年2月—2020年2月濮阳市人民医院收治的120例原发性痛经患者为研究对象，将患者按随机数字表法分为对照组和治疗组，每组各60例。对照组患者经前2～3 d开始口服布洛芬缓释胶囊，1粒/次，2次/d。治疗组在对照组治疗的基础上经前2～3 d温水冲服少腹逐瘀颗粒，1袋/次，2次/d。两组患者连续给药7 d，1个月经周期为1个疗程，连续给药3个疗程后观察效果。观察两组的临床疗效，比较两组的前列腺素E₂（PGE₂）、前列腺素F_2α（PGF_2α）、PGF_2α/PGE₂、人血清P物质（SP）、视觉模拟评分（VAS）、搏动指数（PI）、阻力指数（RI）、收缩期峰值/舒张期峰值（A/B）。结果 治疗后，治疗组患者总有效率（93.33%）明显高于对照组（78.33%），两组比较差异具有统计学意义（P<0.05）。治疗后，两组的PGE₂水平明显升高，PGF_2α、PGF_2α/PGE₂、SP水平明显降低，差异有统计学意义（P<0.05）；治疗后，治疗组的PGE₂水平明显高于对照组，PGF_2α、PGF_2α/PGE₂、SP水平明显低于对照组，差异有统计学意义（P<0.05）。治疗后，两组患者VAS评分均明显降低，差异具有统计学意义（P<0.05）；治疗后，治疗组患者VAS评分明显低于对照组，差异具有统计学意义（P<0.05）。治疗后，两组患者PI、RI、A/B均明显降低，差异具有统计学意义（P<0.05）；治疗后，治疗组患者PI、RI、A/B均低于对照组，差异有统计学意义（P<0.05）。结论 少腹逐瘀颗粒联合布洛芬缓释胶囊治疗原发性痛经具有较好的临床疗效，可以减轻患者疼痛程度，改善患者子宫动脉血流动力学和血清因子水平。

Objective To observe the clinical efficacy of Shaofu Zhuyu Granules combined with Ibuprofen Sustained-release Capsules in treatment of primary dysmenorrhea. Methods Patients (120 cases) with primary dysmenorrhea in Puyang People’s Hospital from February 2018 to February 2020 were randomly divided into control and treatment groups, and each group had 60 cases. Patients in the control group were po administered with Ibuprofen Sustained-release Capsules before menstruation for 2 — 3 d, 1 grain/time, once daily. Patients in the treatment group were po administered with Shaofu Zhuyu Granules before menstruation for 2 — 3 d on the basis of the control group, 1 bag/time, twice daily. Patients in two groups were treated for 7 d, and one menstrual cycle was a course of treatment, and three courses were given continuously. After treatment, the clinical efficacies were evaluated, and PGE₂, PGF_2α, PGF_2α/PGE₂, SP, VAS, PI, RI, and A/B in two groups were compared. Results After treatment, the total effective rate of the treatment group (93.33%) was significantly higher than that of the control group (78.33%), and the difference between two groups was statistically significant (P<0.05). After treatment, the levels of PGE₂ in the two groups were significantly increased, but the levels of PGF_2α, PGF_2α/PGE₂ and SP were significantly decreased (P<0.05). After treatment, the level of PGE₂ in the treatment group was significantly higher than that in the control group, but the levels of PGF_2α, PGF_2α/PGE₂, and SP in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the VAS scores of two groups were significantly decreased, and the difference was statistically significant (P<0.05). After treatment, the VAS score of the treatment group was significantly lower than that of the control group, and the difference was statistically significant (P<0.05). After treatment, PI, RI, and A/B of two groups were significantly decreased, and the difference was statistically significant (P<0.05). After treatment, PI, RI, and A/B of the treatment group were lower than those of the control group, and the difference was statistically significant (P<0.05). Conclusion Shaofu Zhuyu Granules combined with Ibuprofen Sustained-release Capsules has clinical curative effect in treatment of primary dysmenorrhea, can reduce the pain degree of patients, improve the uterine artery hemodynamics and serum factor levels.

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