目的 探讨酒石酸西尼必利片联合胃复春片治疗慢性萎缩性胃炎的临床疗效。方法 选取2018年1月—2019年3月天津中医药大学第一附属医院收治的120例慢性萎缩性胃炎患者作为研究对象，按照随机数字表法将所有患者分为对照组和治疗组，每组各60例。对照组口服胃复春片，4片/次，3次/d。治疗组在对照组的基础上饭前15 min口服酒石酸西尼必利片，1 mg/次，3次/d。两组患者连续治疗12周。观察两组临床疗效，比较两组的临床症状评分、胃黏膜炎症病理评分、胃泌素（GAS）、胃动素（MTL）及谷胱甘肽过氧化物酶（GSH-Px）、前列腺素E₂（PGE₂）。结果 治疗后，治疗组的临床总有效率为93.33%，明显高于对照组80.00%，差异具有统计学意义（P<0.05）。治疗后，两组患者胃脘疼痛评分、胃中嘈杂评分、嗳气泛酸评分、胃黏膜炎症病理评分均较治疗前明显降低（P<0.05）；并且治疗后治疗组患者临床症状评分、胃黏膜炎症病理评分均明显低于对照组（P<0.05）。治疗后，两组患者GAS、MTL水平均较治疗前明显降低，GSH-Px、PGE₂水平较治疗前明显升高（P<0.05）；治疗后，治疗组患者GAS、MTL水平明显低于对照组，GSH-Px、PGE₂水平明显高于对照组（P<0.05）。结论 酒石酸西尼必利片联合胃复春片治疗慢性萎缩性胃炎的疗效确切，能有效改善临床症状、减轻胃黏膜炎症。

Objective To investigate the effect of Cinitapride Hydrogen Tartrate Tablets combined with Weifuchun Tablets in treatment of chronic atrophic gastritis. Methods Patients (120 cases) with chronic atrophic gastritis in the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine from January 2018 to March 2019 were randomly divided into control and treatment groups, and each group had 60 cases. Patients in the control group were po administered with Weifuchun Tablets, 4 tablets/time, three times daily. Patients in the treatment group were po administered with Cinitapride Hydrogen Tartrate Tablets before meals for 15 min on the basis of the control group, 1 tablet/time, three times daily. Patients in two groups were treated for 12 weeks. After treatment, the clinical efficacies were evaluated, and clinical symptom scores, gastric mucosal inflammation pathology scores, GAS, MTL, GSH-Px, and PGE₂ in two groups were compared. Results After treatment, the total effective rate of the treatment group was 93.33%, which was significantly higher than that of the control group (80.00%) (P<0.05). After treatment, the stomachache score, gastric noise score, belching pantothenic acid score, and gastric mucosal inflammation pathology score in two groups were significantly lower than those before treatment (P<0.05). After treatment, the clinical symptom score and gastric mucosal inflammation pathology score in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the levels of GAS and MTL in the two groups were significantly lower than those before treatment, but the levels of GSH-Px and PGE₂ were significantly higher than those before treatment (P<0.05). After treatment, the levels of GAS and MTL in the treatment group were significantly lower than those in the control group, while the levels of GSH-Px and PGE₂ in the treatment group were significantly higher than those in the control group (P<0.05). Conclusion Cinitapride Hydrogen Tartrate Tablets combined with Weifuchun Tablets has clinical curative effect in treatment of chronic atrophic gastritis, can effectively improve the clinical symptoms, reduce the inflammation of gastric mucosa, with good clinical safety.

R975