目的 探讨独一味胶囊联合醋酸地塞米松口腔贴片治疗复发性口疮的临床疗效。方法 选取2019年2月—2019年7月白银市第三人民医院收治的80例复发性口疮患者为研究对象，根据随机数字表法将所有患者分为对照组和治疗组，每组各40例。对照组给予醋酸地塞米松口腔贴片，贴于患处，1片/次，1次/d。治疗组在对照组治疗的基础上口服独一味胶囊，0.6 g/次，3次/d。两组患者连续治疗7 d。观察临床疗效，比较两组的消肿时间、溃疡愈合时间、疼痛消失时间、血清炎症因子和免疫细胞水平以及疼痛程度。结果 治疗后，治疗组的总有效率97.50%明显高于对照组的75.00%，差异有统计学意义（P<0.05）。治疗后，治疗组的消肿时间、溃疡愈合时间、疼痛消失时间均短于对照组，差异有统计学意义（P<0.05）。治疗后，两组的血清转化生长因子-β₁（TGF-β₁）水平明显升高，肿瘤坏死因子-α（TNF-α）、白细胞介素-8（IL-8）水平明显降低，差异有统计学意义（P<0.05）；治疗后，治疗组的TGF-β₁水平高于对照组，TNF-α、IL-8水平低于对照组，差异有统计学意义（P<0.05）。治疗后，两组的CD4⁺、CD4⁺/CD8⁺、自然杀伤（NK）细胞明显升高，差异有统计学意义（P<0.05）；治疗后，治疗组的CD4⁺、CD4⁺/CD8⁺、NK细胞高于对照组，差异有统计学意义（P<0.05）。治疗后，两组视觉模拟评分法（VAS）评分均明显降低，差异有统计学意义（P<0.05）；治疗后，治疗组VAS评分降低更明显，差异有统计学意义（P<0.05）。结论 独一味胶囊联合醋酸地塞米松口腔贴片可提高复发性口疮的疗效，改善临床症状和免疫功能，促进创面愈合。

Objective To investigate the clinical efficacy of Duyiwei Capsules combined with Dexamethasone Acetate Oral Mucoadhesive Patches in treatment of recurrent aphthous ulcer. Methods Patients (80 cases) with recurrent aphthous ulcer in Baiyin Third People’s Hospital from February 2019 to July 2019 were randomly divided into control and treatment groups, and each group had 40 cases. Patients in the control group were given Dexamethasone Acetate Oral Mucoadhesive Patches, pasted on the affected area, 1 paste/time, once daily. Patients in the treatment group were po administered with Duyiwei Capsules on the basis of the control group, 0.6 g/time, three times daily. Patients in two groups were treated for 7 d. After treatment, the clinical efficacies were evaluated, and detumescence time, ulcer healing time and pain disappearance time, the serum levels of inflammatory factors and lymphocytes, and pain intensity in two groups were compared. Results After treatment, the total effective rate of the treatment group was 97.50%, which was significantly higher than that of the control group (75%), with a statistically significant difference (P<0.05). After treatment, the detumescence time, ulcer healing time, and pain disappearance time in the treatment group were shorter than those in the control group, the difference was statistically significant (P<0.05). After treatment, the levels of TGF-β₁ in two groups were significantly increased, but the levels of TNF-α and IL-8 in two groups were significantly decreased, and the difference was statistically significant (P<0.05). After treatment, the levels of TGF-β₁ in the treatment group were higher than those in the control group, but the levels of TNF-α and IL-8 in the treatment group were lower than those in the control group, and the difference was statistically significant (P<0.05). After treatment, CD4⁺, CD4⁺/CD8⁺, and NK cells in the two groups were significantly increased, and the difference was statistically significant (P<0.05). After treatment, CD4⁺, CD4⁺/CD8⁺, and NK cells in the treatment group were higher than those in the control group, and the difference was statistically significant (P<0.05). After treatment, the VAS scores of two groups were significantly decreased, and the difference was statistically significant (P<0.05). After treatment, the VAS score of the treatment group was significantly lower than that of the control group, and the difference was statistically significant (P<0.05). Conclusion Duyiwei Capsules combined with Dexamethasone Acetate Oral Mucoadhesive Patches can improve the curative effect of recurrent aphthous ulcer, improve the clinical symptoms and immune function, and promote the wound healing.

R988.2

天津市医院协会医院管理研究项目（2018zc11）