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[摘要]
目的 探讨骨松宝颗粒联合依降钙素治疗骨质疏松症的临床疗效。方法 选取于2017年4月—2020年4月南阳市中心医院收治的128例骨质疏松症患者,根据随机数表法分为对照组(64例)和治疗组(64例)。对照组肌肉注射依降钙素注射液,10 U/次,2次/周。治疗组在对照组的基础上口服骨松宝颗粒治疗,5 g/次,3次/d。两组均治疗1个月。观察两组的临床疗效,比较两组平均骨密度(BMD)、骨钙素(BGP)、Ⅰ型胶原羧基末端交联肽(β-CTX)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、Oswestry功能障碍指数(ODI)评分的变化情况。结果 治疗后,治疗组总有效率89.06%,显著高于对照组71.88%(P<0.05)。治疗后,两组BMD、BGP显著升高,但β-CTX、IL-6、TNF-α显著下降(P<0.05);治疗后,治疗组BMD、BGP高于对照组,而β-CTX、IL-6、TNF-α低于对照组(P<0.05)。治疗后,两组患者ODI评分均显著下降(P<0.05);且治疗组低于对照组(P<0.05)。结论 骨松宝颗粒联合依降钙素治疗骨质疏松症疗效确切,可改善骨转换因子和炎症细胞因子,降低ODI评分,具有一定的临床推广应用价值。
[Key word]
[Abstract]
Objective To investigate the effect of Gusongbao Granules combined with elcatonin in treatment of osteoporosis. Methods 128 patients with osteoporosis admitted in Nanyang Central Hospital from April 2017 to April 2020 were selected. According to the random number table method, they were divided into control group (n = 64) and treatment group (n = 64). Patients in the control group were im administered with Elcatonin Injection, 10 U/time, twice weekly. Patients in the treatment group were po administered with Gusongbao Granules on the basis of the control group, 5 g/time, three times daily. Both groups were treated for 1 month. The clinical effects of two groups were observed, and changes of average bone mineral density (BMD), osteocalcin (BGP), collagen type Ⅰ carboxyl terminal crosslinking peptide (β-CTX), interleukin 6 (IL-6), tumor necrosis factor α (TNF-α), oswestry disability index (ODI) score in two groups were compared. Results After treatment, the total effective rate of the treatment group was 89.06%, significantly higher than that of the control group (71.88%, P<0.05). After treatment, BMD and BGP were significantly increased in both groups, but β-CTX, IL-6 and TNF-α were significantly decreased (P<0.05). After treatment, BMD and BGP of the treatment group were higher than those of the control group, while β-CTX, IL-6 and TNF-α of the treatment group were lower than those of the control group (P<0.05). After treatment, ODI score of patients in both groups decreased significantly (P<0.05). ODI score in the treatment group was lower than that in the control group (P<0.05). Conclusion Gusongbao Granules combined with elcatonin has curative effect in treatment of osteoporosis, and can improve bone conversion factors and inflammatory cytokines, and also can reduce ODI score, which has certain clinical application value.
[中图分类号]
R977
[基金项目]
河南省科技发展计划项目(182102510055)