[关键词]
[摘要]
目的 探讨复方大红袍止血片联合复方醋酸棉酚治疗功能性子宫出血的临床疗效。方法 选取2018年5月—2020年5月在郑州大学附属南阳市中心医院进行治疗的152例功能性子宫出血患者为研究对象,根据就诊顺序分为对照组(76例)和治疗组(76例)。对照组口服复方醋酸棉酚片,20 mg/次,1次/d;治疗组患者在对照组基础上口服复方大红袍止血片,2 g/次,3次/d。两组均治疗8周进行效果比较。比较两组的临床疗效,观察两组临床症状改善时间、激素水平和血清学指标情况。结果 经治疗,对照组总有效率为81.58%,显著低于治疗组97.37%(P<0.05)。经治疗,治疗组在淋漓不止、腰膝酸软、小腹坠痛、经行不畅、经血色淡等症状改善时间上均显著短于对照组(P<0.05)。经治疗,两组血清雌二醇(E2)、促卵泡生成素(FSH)、促黄体生成素(LH)水平均较治疗前显著降低(P<0.05);且治疗后,治疗组性激素水平显著低于对照组(P<0.05)。经治疗,两组血清促血管生成素-2(Ang-2)、水通道蛋白4(AQP4)均显著降低,但血管内皮生长因子(VEGF)、β内啡肽(β-EP)水平均显著升高(P<0.05);治疗后,治疗组Ang-2、AQP4水平显著低于对照组,但VEGF、β-EP显著高于对照组(P<0.05)。结论 复方大红袍止血片联合复方醋酸棉酚治疗功能失调性子宫出血具有较好的临床疗效,可有效改善患者的临床症状,还可有效改善机体血清细胞因子水平,具有一定的临床推广应用价值。
[Key word]
[Abstract]
Objective To investigate the clinical efficacy of Compound Dahongpao Zhixue Tablets combined with compound gossypol acetate in treatment of functional uterine bleeding. Methods A total of 152 patients with functional uterine bleeding who were treated in Nanyang Central Hospital Affiliated to Zhengzhou University from May 2018 to May 2020 were selected as the research objects, and they were divided into control group (76 cases) and treatment group (76 cases) according to the order of treatment. Patients in the control group were po administered with Compound Gosspol Acetate Tablets, 20 mg/time, once daily. Patients in the treatment group were po administered with Compound Dahongpao Zhixue Tablets on the basis of the control group, 2 g/time, three times daily. The two groups were compared after 8 weeks of treatment. The clinical efficacy of the two groups was compared, and the improvement time of clinical symptoms, hormone levels and serological indicators of the two groups were observed. Results After treatment, the total effective rate of the control group was 81.58%, significantly lower than that of the treatment group (97.37%) (P<0.05). After treatment, the improvement time of symptoms in the treatment group was significantly shorter than that in the control group (P<0.05). After treatment, serum estradiol (E2), follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels in both groups were significantly lower than those before treatment (P<0.05). After treatment, the level of sex hormones in the treatment group was significantly lower than that in the control group (P<0.05). After treatment, the serum levels of angiogenin-2 (Ang-2) and aquaporin 4 (AQP4) were significantly decreased in both groups, but the levels of vascular endothelial growth factor (VEGF) and β endorphin (β-EP) were significantly increased in both groups (P<0.05). After treatment, the levels of ANG-2 and AQP4 in the treatment group were significantly lower than those in the control group, but the levels of VEGF and β-EP in the treatment group were significantly higher than those in the control group (P<0.05). Conclusion Compound Dahongpao Zhixue Tablets combined with compound gossypol acetate has a good clinical effect in treatment of functional uterine bleeding, and can effectively improve the clinical symptoms of patients, and also can effectively improve the body's serum cytokine level, which has certain clinical application value.
[中图分类号]
R984
[基金项目]
河南省科技攻关计划项目(201602384)