目的 探讨猴耳环消炎片联合法莫替丁片治疗急性胃肠炎的临床疗效。方法 选择2019年4月—2020年4月在郑州大学附属郑州中心医院治疗的急性肠胃炎患者84例，采用双色球随机分组法分成对照组与治疗组，各42例。对照组口服法莫替丁片，20 mg/次，2次/d；治疗组在对照组基础上口服猴耳环消炎片，0.96 g/次，3次/d。两组治疗7 d。比较两组临床疗效，观察两组临床症状改善时间和血清学指标。结果 经治疗，对照组患者有效率为80.95%，显著低于治疗组（97.62%，P<0.05）。经治疗，治疗组患者在腹痛、腹泻、呕吐等症状改善时间上均短于对照组（P<0.05）。经治疗，两组血清超敏C反应蛋白（hs-CRP）、白细胞介素-6（IL-6）、降钙素原（PCT）、肿瘤坏死因子-α（TNF-α）水平均显著下降（P<0.05），且治疗后治疗组血清学指标低于对照组（P<0.05）。结论 急性胃肠炎患者给予猴耳环消炎片和法莫替丁片共同治疗不仅促进患者临床症状改善，还有利于机体炎症反应降低，有着良好的临床应用价值。

Objective To explore the clinical effect of Houerhuan Xiaoyan Tablets combined with famotidine in treatment of acute gastroenteritis. Methods Patients (84 cases) with acute gastroenteritis in Zhengzhou Central Hospital Affiliated to Zhengzhou University from April 2019 to April 2020 were divided into control (42 cases) and treatment (42 cases) groups based on different treatments. Patients in the control group were po administered with Famotidine Tablets, 20 mg/time, twice daily. Patients in the treatment group were po administered with Houerhuan Xiaoyan Tablets on the basis of the control group, 0.96 g/time, three times daily. Patients in two groups were treated for 7 d. After treatment, the clinical efficacy of the two groups was compared, and the improvement time and serological indexes of the two groups were observed. Results After treatment, the clinical efficacy and in the control and treatment groups was 80.95% and 97.62% respectively, and there were differences between two groups (P<0.05). After treatment, the improvement time of abdominal pain, diarrhea and vomiting in the treatment group was significantly earlier than that in the control group (P<0.05). After treatment, serum levels of hs-CRP, IL-6, PCT and TNF-α in both groups were significantly decreased (P<0.05), and the serological indexes of the treatment group were lower than those of the control group (P<0.05). Conclusion Houerhuan Xiaoyan Tablets combined with famotidine in treatment of acute gastroenteritis can effectively improve the clinical symptoms, reduce inflammation, which has a certain clinical application value.

R975

河南省科学技术厅支撑基金项目（152102310006）