[关键词]
[摘要]
目的 探讨哮喘宁颗粒联合硫酸沙丁胺醇气雾剂治疗支气管哮喘慢性持续期患者的临床疗效。方法 选取2017年9月—2019年11月郑州大学第五附属医院收治的98例支气管哮喘慢性持续期患者为研究对象,根据抽签法将患者分为对照组(49例)和治疗组(49例)。对照组吸入复方硫酸沙丁胺醇气雾剂,早晚各1吸。治疗组在对照组治疗的基础上口服哮喘宁颗粒,25 g/次,2次/d。两组均治疗12周。观察两组的临床疗效,比较两组的肺功能、血清炎性因子。结果 治疗后,治疗组的总有效率为93.88%,高于对照组的75.51%(P<0.05)。治疗后,两组用力肺活量(FVC)、第一秒用力呼气量(FEV1)、最大呼气峰流速(PEF)均升高(P<0.05),且治疗组肺功能高于对照组(P<0.05)。治疗后,两组干扰素-γ(IFN-γ)、白细胞介素-4(IL-4)、白细胞介素-17(IL-17)水平降低,白细胞介素-10(IL-10)水平升高(P<0.05),且治疗组IFN-γ、IL-4、IL-17水平低于对照组,IL-10水平高于对照组(P<0.05)。结论 哮喘宁颗粒联合硫酸沙丁胺醇气雾剂治疗支气管哮喘慢性持续期具有较好的疗效,可明显改善肺功能,减轻炎症反应,且安全性较好。
[Key word]
[Abstract]
Objective To investigate the clinical effect of Xiaochuanning Granules combined with Compound Salbutamol Sulfate Aerosol in treatment of chronic persistent bronchial asthma. Methods Patients (98 cases) with chronic persistent bronchial asthma in the First Affiliated Hospital of Zhengzhou University from September 2017 to November 2019 were randomly divided into the control group (49 cases) and the treatment group (49 cases). Patients in the control group inhaled Compound Salbutamol Sulfate Aerosol, once in the morning and once in the evening. Patients in the treatment group were po administered with Xiaochuanning Granules on the basis of the control group, 25 g/time, twice daily. Patients in two groups were treated for 12 weeks. After treatment, the clinical efficacies were evaluated, and lung function indexes and serum inflammatory factors in two groups were compared. Results After treatment, the total effective rate of the treatment group was 93.88%, which was higher than 75.51% of the control group (P<0.05). After treatment, the FVC, FEV1, and PEF were increased (P<0.05), and the lung function of the treatment group was higher than that of the control group (P<0.05). After treatment, the levels of IFN-γ, IL-4, and IL-17 in the two groups were decreased, but the level of IL-10 was increased (P<0.05). And the levels of IFN-γ, IL-4, and IL-17 in the treatment group were lower than those in the control group, but the level of IL-10 in the treatment group was higher than that in the control group (P<0.05). Conclusion Xiaochuanning Granules combined with Compound Salbutamol Sulfate Aerosol has clinical curative effect in the treatment of chronic persistent bronchial asthma, can significantly reduce the inflammatory response, and improve the lung function, with good safety.
[中图分类号]
R974
[基金项目]
河南省医学科技攻关计划项目(2017T03096)