目的 探讨脑心通胶囊联合胞磷胆碱钠胶囊治疗急性脑梗死恢复期的临床疗效。方法 选取2019年4月—2020年4月在天津市第五中心医院治疗的脑梗死恢复期患者126例，随机分为对照组和治疗组，每组各63例。对照组患者口服胞磷胆碱钠胶囊，2粒/次，3次/d。治疗组在对照组的基础上口服脑心通胶囊治疗，3粒/次，3次/d。两组患者均治疗4周。观察两组患者临床疗效，同时比较治疗前后两组患者神经功能缺损评分和Barthel指数，全血高切黏度、全血低切黏度、血浆黏度和红细胞压积，及血小板蛋白激酶C（PKC）、五正聚蛋白3（PTX3）、血管紧张素Ⅱ（Ang ΙΙ）和α颗粒膜蛋白（GMP-140）水平。结果 治疗后，对照组和治疗组临床有效率分别为77.78%和92.06%，两组比较差异有统计学意义（P<0.05）。治疗后，两组Barthel指数、全血高切黏度、全血低切黏度、血浆黏度和红细胞压积均明显高于治疗前（P<0.05），且治疗组显著高于对照组（P<0.05）。治疗后，两组患者神经功能缺损评分、PKC、PTX3、Ang ΙΙ和GMP-140水平明显降低（P<0.05），且治疗组比对照组降低更为显著（P<0.05）。结论 脑心通胶囊联合胞磷胆碱钠胶囊可改善神经功能缺损和血液流变学指标，降低PKC、PTX3、Ang ΙΙ和GMP-140水平，提高患者的日常生活活动能力。

Objective To investigate the effect of Naoxintong Capsules combined with Citicoline Sodium Capsules in treatment of acute cerebral infarction in convalescent stage. Methods Patients (126 cases) with acute cerebral infarction in convalescent stage in Tianjin Fifth Central Hospital from April 2019 to April 2020 were randomly divided into control and treatment groups, and each group had 63 cases. Patients in the control group were po administered with Citicoline Sodium Capsules, 2 grains/time, three times daily. Patients in the treatment group were po administered with Naoxintong Capsules on the basis of the control group, 3 grains/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the neurological deficit score, Barthel index, whole blood high shear viscosity, whole blood low shear viscosity, plasma viscosity and hematocrit, and the levels of PKC, PTX3, Ang Ⅱ and GMP-140 in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 77.78% and 92.06% respectively, and there were differences between two groups (P<0.05). After treatment, Barthel index, whole blood high shear viscosity, whole blood low shear viscosity, plasma viscosity and hematocrit in two groups were significantly increased (P<0.05), and these indexes in the treatment group were significantly higher than those in the control group (P<0.05). After treatment, the levels of the neurological deficit score, PKC, PTX3, Ang Ⅱ, and GMP-140 in two groups were significantly decreased (P<0.05), and which in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Naoxintong Capsules combined with Citicoline Sodium Capsules can improve neurological impairment and hemorheology indexes, reduce PKC, PTX3, Ang Ⅱ, and GMP-140 levels, and improve activities of daily living of patients.

R971

天津市卫生局科技支撑计划项目（2019BWKY028）