目的 探讨川贝枇杷胶囊联合头孢哌酮治疗慢性支气管炎急性发作的临床疗效。方法 抽取2018年10月-2020年1月在中国平煤神马集团职业病防治医院治疗的慢性支气管炎急性发作患者84例，依据药物治疗方案分为对照组和治疗组，每组各42例。对照组患者静脉滴注注射用头孢哌酮钠，2.0 g/次加入生理盐水200 mL，2次/d；治疗组在该基础上口服川贝枇杷胶囊，3粒/次，3次/d。两组患者均连续治疗10 d。观察两组患者临床疗效，同时比较治疗前后两组患者血清肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）和IL-8水平及症状和体征消失时间。结果 治疗后，对照组和治疗组临床总有效率分别为85.71%、97.62%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组TNF-α、IL-6、IL-8水平均明显降低（P<0.05），且治疗组患者明显低于对照组（P<0.05）。治疗期间，治疗组患者喘息、咳嗽、咳痰、发热等消失时间均明显短于对照组（P<0.05）。结论 川贝枇杷联合头孢哌酮治疗慢性支气管炎急性发作取得了满意疗效，且安全性好，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Chuanbei Pipa Capsules combined with cefoperazone in treatment of acute attack of chronic bronchitis. Methods Patients (84 cases) with acute attack of chronic bronchitis in Occupational Disease Prevention and Therapeutic Hospital of China Pingmei Shenma Group from October 2018 to January 2020 were divided into control and treatment groups based on different treatments, and each group had 42 cases. Patients in the control group were iv administered with Cefoperazone sodium for injection, 2 g added into normal saline 200 mL, twice daily. Patients in the treatment group were po administered with Chuanbei Pipa Capsules on the basis of the control group, 3 grains/time, three times daily. Patients in two groups were treated for 10 d. After treatment, the clinical efficacy was evaluated, and the serum levels of TNF-α, IL-6 and IL-8, and the disappearance time of symptoms and signs in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 85.71% and 97.62%, respectively, and there were differences between two groups (P<0.05). After treatment, the serum levels of TNF-α, IL-6, and IL-8 in two groups were significantly decreased (P<0.05), and which in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the disappearance time of wheezing, coughing, expectoration, fever in the treatment group was significantly shorter than that in the control group (P<0.05). Conclusion Chuanbei Pipa Capsules combined with cefoperazone has satisfactory curative effect and good safety in treatment of acute attack of chronic bronchitis, which has a certain clinical application value.

R974