[关键词]
[摘要]
目的 探讨金莲花口服液联合替硝唑胶囊治疗牙周炎的临床疗效。方法 选取2018年1月-2020年1月在天津市第三中心医院分院就诊的80例(患牙105颗)牙周炎患者作为研究对象,根据随机数字表法将所有患者分为对照组(40例,患牙51颗)和治疗组(40例,患牙54颗)。对照组口服替硝唑胶囊,0.25 g/次,1次/d。治疗组在对照组治疗的基础上口服金莲花口服液,10 mL/次,3次/d,含漱1 min后吞服。两组患者连续治疗5 d。观察两组的临床疗效,比较两组的牙周指标菌斑指数、出血指数、探诊深度和龈沟液炎症因子单核细胞趋化蛋白-1(MCP-1)、白细胞介素-1β(IL-1β)、白细胞介素-8(IL-8)水平。结果 治疗后,对照组的总有效率为80.00%,治疗组的总有效率为95.00%,差异有统计学意义(P<0.05)。治疗后,两组的菌斑指数、出血指数、探诊深度均显著降低(P<0.05);治疗后,治疗组的菌斑指数、出血指数、探诊深度低于对照组,差异有统计学意义(P<0.05)。治疗后,两组龈沟液MCP-1、IL-1β、IL-8水平均明显降低(P<0.05);治疗后,治疗组的龈沟液MCP-1、IL-1β、IL-8水平低于对照组,差异有统计学意义(P<0.05)。结论 金莲花口服液联合替硝唑胶囊治疗牙周炎具有较好的疗效,可减轻牙周组织症状,减轻炎症反应。
[Key word]
[Abstract]
Objective To investigate the clinical efficacy of Jinlianhua Oral Liquid combined with Tinidazole Capsules in treatment of periodontitis. Methods Patients (80 cases, 105 affected teeth) with periodontitis in the Branch of Tianjin Third Central Hospital from January 2018 to January 2020 were randomly divided into the control group (40 cases, 51 affected teeth) and the treatment group (40 cases, 54 affected teeth). Patients in the control group were po administered with Tinidazole Capsules, 0.25 g/time, once daily. Patients in the treatment group were po administered with Jinlianhua Oral Liquid on the basis of the control group, 10 mL/time, three times daily, gargled for 1 min before swallowing. Patients in two groups were treated for 5 d. After treatment, the clinical efficacies were evaluated, and the plaque index, the bleeding index, the probing depth, and the levels of inflammatory factor MCP-1, IL-1β and IL-8 in gingival crevicular fluid of two groups were compared. Results After treatment, the total effective rate of the treatment group was 95.00%, and that of the control group was 80.00%, and the difference between the two groups was statistically significant (P<0.05). After treatment, the plaque index, the bleeding index and the probing depth of two groups were significantly decreased (P<0.05); after treatment, the periodontal indexes plaque index, the bleeding index and the probing depth of the treatment group were lower than those of the control group, and the difference between the two groups was statistically significant (P<0.05). After treatment, the levels of MCP-1, IL-1β and IL-8 in gingival crevicular fluid of two groups were significantly decreased (P<0.05). After treatment, the levels of MCP-1, IL-1β and IL-8 in gingival crevicular fluid of the treatment group were lower than those of the control group, and the difference between the two groups was statistically significant (P<0.05). Conclusion Jinlianhua Oral Liquid combined with Tinidazole Capsules has clinical curative effect in treatment of periodontitis, can reduce periodontal tissue symptoms and inflammatory reaction.
[中图分类号]
R988.2
[基金项目]
天津市科技计划项目(16JCQNJC10600/191072)