目的 探讨橘红痰咳液联合莫西沙星注射液治疗痰浊阻肺型老年社区获得性肺炎的临床效果。方法 选取2018年11月-2019年2月天津中医药大学第一附属医院收治的120例老年痰浊阻肺型社区获得性肺炎患者，将所有患者随机分为对照组和治疗组，每组各60例。对照组静脉滴注盐酸莫西沙星氯化钠注射液，250 mL/次，1次/d。治疗组患者在对照组治疗基础上口服橘红痰咳液，20 mL/次，3次/d，两组均连续治疗7 d。观察两组的临床疗效和影像学吸收情况，比较两组临床症状缓解时间和治疗前后白细胞计数（WBC）、C反应蛋白（CRP）、降钙素原（PCT）的变化。结果 治疗后，治疗组总有效率为95.00%，显著高于对照组的88.33%（P<0.05）。治疗组患者体温恢复正常、咳嗽消失时间均显著短于对照组（P<0.05）。治疗后，两组患者WBC、CRP、PCT水平较治疗前明显降低（P<0.05）；且治疗后，治疗组这些炎症指标比较降低更显著（P<0.05）。治疗后，对照组影像学总吸收率是98.33%，治疗组是96.66%，两组比较差异无统计学意义。结论 橘红痰咳液联合莫西沙星注射液治疗痰湿阻肺型老年社区获得性肺炎患者具有较好的临床疗效，可缩短症状缓解时间，减轻炎症反应程度，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Juhong Tanke Liquid combined with moxifloxacin in treatment of community-acquired pneumonia of the elderly with turbid phlegm obstructing lung. Methods 120 Patients with community-acquired pneumonia of the elderly with turbid phlegm obstructing lung who were treated in the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine from November 2018 to February 2019 were selected as the research objects, and they were randomly divided into control group (60 cases) and treatment group (60 cases). Patients in the control group were iv administered with Moxifloxacin Hydrochloride and Sodium Chloride Injection, 250 mL/time, once daily. Patients in the treatment group were po administered with Juhong Tanke Liquid on the basis of the control group, 20 mL/time, three times daily. Patients in two groups were treated for 7 d. After treatment, the clinical efficacy and imaging absorption of the two groups were observed, and the changes of white blood cell count (WBC), C-reactive protein (CRP) and procalcitonin (PCT) before and after treatment were compared between the two groups. Results After treatment, the total effective rate of the treatment group 95.00% was significantly higher than that of the control group (88.33%, P<0.05). After treatment, the temperature returned to normal and cough disappeared time in the treatment group was significantly shorter than that in the control group (P<0.05). After treatment, WBC, CRP, and PCT levels in the two groups were significantly lower than before treatment (P<0.05). After treatment, the reduction of these inflammatory indicators in the treatment group was more significant (P<0.05). After treatment, the total imaging absorption rate was 98.33% in the control group and 96.66% in the treatment group, and there was no statistically significant difference between the two groups. Conclusion Juhong Tanke Liquid combined with moxifloxacin has good clinical effect in treatment of community-acquired pneumonia of the elderly with turbid phlegm obstructing lung, and can shorten the remission of symptoms, and also can reduce the inflammation degree, which has certain clinical application value.

R974

天津中医药大学第一附属医院“拓新工程”科研课题（201909）