目的 探讨金花清感颗粒联合帕拉米韦治疗儿童流行性感冒的临床疗效。方法 选取2017年1月-2020年1月在天津市宁河区医院进行治疗的206例流行性感冒患儿为研究对象，根据就诊顺序分为对照组（103例）和治疗组（103例）。对照组静脉滴注帕拉米韦氯化钠注射液，10 mg/kg，1次/d。治疗组在对照组基础上口服金花清感颗粒，1袋/次，2次/d。两组连续治疗5 d后进行效果对比。结果 经治疗，治疗组总有效率是98.06%，显著高于对照组82.52%（P<0.05）。经治疗，治疗组高热、咳嗽、咽痛、鼻塞等临床症状消失时间显著短于对照组（P<0.05）。经治疗，两组血清超敏C反应蛋白（hs-CRP）、白细胞计数（WBC）、中性粒细胞百分比（NEU）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）水平均显著下降（P<0.05）；且治疗后，治疗组这些血清学指标显著低于对照组（P<0.05）。结论 金花清感颗粒联合帕拉米韦治疗流行性感冒患儿具有较好的临床疗效，不仅能促进临床症状改善，还可降低机体炎症因子水平，具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy of Jinhua Qinggan Granules combined with pramivir in treatment of children with influenza. Methods 206 Children with influenza who were treated in Tianjin Ninghe Hospital from January 2017 to January 2020 were selected as the research objects, and they were divided into control group (103 cases) and treatment group (103 cases) according to the order of treatment. Patients in the control group were iv administered with Peramivir and Sodium Chloride Injection, 10 mg/kg, once daily. Patients in the treatment group were po administered with Jinhua Qinggan Granules on the control group, 1 bag/time, twice daily. The two groups were compared after 5 d of continuous treatment. Results After treatment, the total effective rate in the treatment group was 98.06%, significantly higher than that in the control group (82.52%) (P<0.05). After treatment, the disappearance time of clinical symptoms such as high fever, cough, sore throat and nasal obstruction in the treatment group was significantly shorter than that in the control group (P<0.05). After treatment, the serum levels of hs-CRP, WBC, NEU, IL-6, and TNF-α significantly decreased in both groups (P<0.05). After treatment, these serological indicators in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Jinhua Qinggan Granule combined with peramivir has good clinical effect in treatment of children with influenza, and can not only promote the improvement of clinical symptoms, but also reduce the level of inflammatory factors in the body, which has a certain clinical application value.

R985

黑龙江省卫生计生委科研课题（2016-155）