肾功能不全是由多种原因共同作用导致的机体酸碱失衡、水电解质紊乱等。该疾病好发于老年群体，临床症状主要表现为贫血、代谢性酸中毒、高血压等，严重者可累及全身多个脏器组织。高尿酸血症可进一步导致老年肾功能不全疾病的发生，进而加重肾功能损害，甚至痛风。此外老年人常用降脂降压、抗生素等药物，更易引发因药物引起的肾损害，故探讨降尿酸药物别嘌醇、非布司他、托匹司他、丙磺舒、苯溴马隆、拉布立酶、培戈洛酶治疗对老年肾功能不全患者肾功能的影响，以期为临床治疗提供参考。

Renal insufficiency is caused by a variety of reasons, which lead to acid-base imbalance of the body, water and electrolyte disorder and so on. The disease predisposes to the elderly. The main clinical symptoms are anemia, metabolic acidosis, hypertension, and so on. In severe cases, multiple organs and tissues of the body can be involved. Hyperuricemia can further lead to the occurrence of renal insufficiency in the elderly, and then aggravate the damage of renal function, even gout. In addition, medications such as lipid and blood pressure lowering and antibiotics are commonly used in the elderly, which are more likely to cause renal damage from drugs. This paper discusses the effects of uric acid lowering drugs, such as allopurinol, febuxostat, topista, probenecid, benzbromarone, labilise, and pegolose on renal function in elderly patients with renal insufficiency, in order to provide reference for clinical treatment.

R983