柚皮素是一种具有多种生物活性的天然黄酮类化合物。但较低的水溶性和生物利用度限制了其临床应用。近年来国内外关于柚皮素纳米脂质体、纳米乳、纳米混悬剂、纳米凝胶、纳米固体分散体和纳米粒在提高溶解度、改善吸收等方面取得了一定进展。通过查阅国内外文献，对近年来柚皮素纳米新剂型研究进行综述，为其后续研发提供必要的思路和参考。

Naringenin is a kind of natural flavonoid compound with multiple active activities. However, the application of naringenin is limited by its low water solubilility and inadequate bioavailability. In recent years, studies on naringenin preparation, including nanoliposome, nanoemulsion, nanosuspension, nanogel, nano-solid dispersion, and nanoparticles, have made some progress in improving the solubility and absorption at home and abroad. This paper summarizes the new formulations of naringenin, and provides necessary ideas and references for the future development.

R944

国家重点研发计划中医药现代化研究重点专项（2018YFC1706700）；黑龙江省自然科学基金资助项目（H201472）