目的 研究糖尿病视网膜病变患者内眼术前结膜囊菌群分布以及药敏分析特点，为糖尿病视网膜病变患者术后眼炎的预防提供临床指导。方法 收集463例糖尿病视网膜病变眼病患者结膜囊分泌物行细菌培养、鉴定及药敏分析。结果 463例糖尿病视网膜病变患者共取样518份棉拭子接种，518份样本中检出菌株286例，检出率55.21%，其中革兰阳性菌检出233株占81.47%，其中表皮葡萄球菌163株（56.99%），棒状杆菌其次27株（9.44%），金黄色葡萄球菌20株（6.99%）；革兰阴性菌检出53株占18.53%，其中鲍曼不动杆菌20株（6.99%），粘质沙雷菌12株（4.20%），大肠埃希菌10株（3.50%）；表皮葡萄球菌、金黄色葡萄球菌对红霉素、头孢他啶、庆大霉素耐药，对万古霉素、左氧氟沙星等喹诺酮类药物敏感；除红霉素、妥布霉素、诺氟沙星外，棒状杆菌对所检测抗生素均较为敏感；鲍曼不动杆菌对哌拉西林耐药。结论 糖尿病视网膜病变患者结膜囊分泌物细菌培养鉴定及药敏分析为术前结膜囊无菌化合理用药的关键，对术后眼内炎症的预防至关重要。

Objective To study the distribution of the conjunctival sac and the characteristics of drug sensitivity analysis in patients with diabetes, and to provide clinical guidance for the prevention of postoperative ophthalmia in diabetic patients. Methods Bacterial culture, identification and drug sensitivity analysis of conjunctival sac secretion from 463 patients with diabetic retinopathy were performed. Results A total of 518 cotton swabs were inoculated in 463 patients with diabetic retinopathy, 286 were detected in 518 samples, the detection rate was 55.21%, of which 233 were Gram-positive, 81.47% were detected, 163 were Staphylococcus epidermidis (56.99%), followed by 27 were Corynebacterium (9.44%) and 20 were Staphylococcus aureus (6.99%), 53 were Gram-negative, 18.53% were detected, 20 were Acinetobacter baumannii (6.99%), 12 were Corynegeria (4.20%), 10 were Staphylococcus escherichia coli (3.50%); Bacteria, Staphylococcus aureus, resistant to erythromycin, ceftazidime, gentamicin, sensitive to vancomycin, levofloxacin and other quinolones; except erythromycin, Corynebacterium is more sensitive to the tested antibiotics; Acinetobacter baumannii is resistant to Piperacillin. Conclusion The identification and drug sensitivity of bacterial culture for diabetic retinopathy is the key to the rational use of the conjunctival sac and the prevention of postoperative endophthalmitis.

R978.1