目的 探讨骨松宝颗粒联合骨化三醇胶丸治疗老年骨质疏松性股骨粗隆间骨折的临床疗效。方法 选取2018年7月-2019年12月新乡医学院第一附属医院收治的82例老年骨质疏松性股骨粗隆间骨折患者，按照随机数字表法将82例患者分为对照组和治疗组，每组各41例。对照组口服骨化三醇胶丸，0.25μg/次，3次/d。治疗组患者在对照组治疗的基础上温水冲服骨松宝颗粒，5 g/次，2次/d。两组患者连续治疗6个月。观察两组的临床疗效，比较两组的视觉模拟评分法（VAS）评分、髋关节功能（Harris）评分、骨密度和血清抗酒石酸酸性磷酸酶5b（TRACP-5b）、胰岛素样生长因子Ⅰ（IGF-Ⅰ）、骨钙素（OC）水平。结果 治疗后，治疗组患者的总有效率比对照组高（95.12%vs 80.49%），差异有统计学意义（P<0.05）。治疗后，两组的VAS评分显著降低，Harris评分显著升高（P<0.05）；且治疗组的VAS评分低于对照组，Harris评分高于对照组（P<0.05）。治疗后，两组的腰椎骨密度明显升高（P<0.05），且治疗组升高的更明显（P<0.05）。治疗后，两组的TRACP-5b水平显著降低，IGF-Ⅰ、OC水平显著升高，差异有统计学意义（P<0.05）；且治疗后治疗组的TRACP-5b水平比对照组低，IGF-Ⅰ、OC水平比对照组高，差异有统计学意义（P<0.05）。结论 骨松宝颗粒联合骨化三醇胶丸治疗老年骨质疏松性股骨粗隆间骨折具有较好的临床疗效，可减轻疼痛程度，改善骨密度，调节血清骨代谢指标。

Objective To investigate the effect of Gusongbao Granules combined with Calcitriol Soft Capsules in treatment of senile osteoporotic intertrochanteric fracture. Methods Elderly patients (82 cases) with osteoporotic intertrochanteric fracture in the First Affiliated Hospital of Xinxiang Medical University from July 2018 to December 2019 were randomly divided into control and treatment groups, and each group had 41 cases. Patients in the control group were po administered with Calcitriol Soft Capsules, 0.25 μg/time, three times daily. Patients in the treatment group were po administered with Gusongbao Granules on the basis of the control group, 5 g/time, twice daily. Patients in two groups were treated for 6 months. After treatment, the clinical efficacies were evaluated, and VAS score, Harris score, bone density, the levels of TRACP-5b, IGF-Ⅰ, and OC in two groups were compared. Results After treatment, the total effective rate of the treatment group was higher than that of the control group (95.12% vs 80.49%) (P<0.05). After treatment, the VAS score of two groups was significantly decreased, but the Harris score was significantly increased (P<0.05); and the VAS score of the treatment group was lower than that of the control group, but the Harris score was higher than that of the control group (P<0.05). After treatment, the bone density of lumbar spine in the two groups increased significantly (P<0.05), and the treatment group was significantly higher than the control group (P<0.05). After treatment, the levels of TRACP-5b in two groups were significantly decreased, but levels of IGF-Ⅰand OC in two groups were significantly increased (P<0.05); and the levels of TRACP-5b in the treatment group were lower than those in the control group, but the level of IGF-Ⅰand OC was higher than that in the control group (P<0.05). Conclusion Gusongbao Granules combined with Calcitriol Soft Capsules has clinical curative effect in treatment of senile osteoporotic intertrochanteric fracture, can relieve pain, improve bone density, and regulate serum bone metabolism indexes.

R977