目的 观察胃苏颗粒联合磷酸铝凝胶治疗胆汁反流性胃炎的临床效果。方法 选择2017年11月-2019年12月在天津市泰达医院治疗的胆汁反流性胃炎患者103例，随机分为对照组（52例）和治疗组（51例）。对照组患者口服磷酸铝凝胶，20 g/次，3次/d。治疗组患者在对照组治疗基础上口服胃苏颗粒，1袋/次，3次/d。两组患者均连续治疗4周。观察两组患者临床疗效，同时比较治疗前后两组患者血管活性肠肽（VIP）、血浆胃动素（MTL）和胆汁反流情况。结果 治疗后，对照组和治疗组临床有效率分别为71.15%和92.16%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组VIP水平显著降低，MTL水平显著升高（P<0.05），且治疗组VIP和MTL水平明显比对照组好（P<0.05）。治疗后，两组最长反流时间、胆汁反流次数和反流总时间占比均明显降低（P<0.05），且治疗组显著低于对照组（P<0.05）。结论 胃苏颗粒联合磷酸铝凝胶治疗胆汁反流性胃炎，可明显缓解黏膜炎症和胆汁反流情况，改善机体VIP和MTL水平，临床疗效较好，安全可靠。

Objective To observe the clinical effect of Weisu Granules combined with Aluminum Phosphate Gel in treatment of bile reflux gastritis. Methods Patients (103 cases) with bile reflux gastritis in Tianjin TEDA Hospital from November 2017 to December 2019 were randomly divided into control (52 cases) and treatment (51 cases) groups. Patients in the control group were po administered with Colloidal Aluminium Phosphate Gel, 20 g/time, three times daily. Patients in the treatment group were po administered with Weisu Granules on the basis of the control group, 1 bag/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the levels of VIP and MTL, bile reflux in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 71.15% and 92.16%, respectively, and there were differences between two groups (P<0.05). After treatment, the VIP levels in two groups were significantly decreased, but the MTL levels in two groups were significantly increased (P<0.05), and the levels of VIP and MTL in the treatment group were significantly better than those in the control group (P<0.05). After treatment, the longest time, frequency and total time of bile reflux in two groups were significantly decreased (P<0.05), and these indicators in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Weisu Granules combined with Colloidal Aluminium Phosphate Gel in treatment of bile reflux gastritis can obviously relieve mucosal inflammation and bile reflux, improve the VIP and MTL levels, which has good clinical efficacy with safety and reliability.

R975