目的 探讨百艾洗液联合奥硝唑阴道栓治疗滴虫性阴道炎的临床疗效。方法 选取2020年2月-2020年6月在漯河市中心医院进行治疗的150例滴虫性阴道炎患者为研究对象，根据就诊顺序分为对照组（75例）和治疗组（75例）。对照组给予奥硝唑阴道栓，每晚将外阴洗净后戴上手套将奥硝唑阴道栓塞入阴道深处，1枚/次，1次/d；治疗组在对照组治疗基础上给予百艾洗液，20 mL用温水稀释至200 mL，用阴道冲洗器冲洗，2次/d。两组均连续治疗10 d。比较两组的临床疗效，观察两组治疗前后症状消失时间、相关评分、血清学指标情况。结果 经治疗，治疗组总有效率是98.67%，显著高于对照组85.33%（P<0.05）。经治疗，治疗组在外阴瘙痒、腰腹疼痛、外阴灼痛、白带异常等临床症状消失时间上均显著短于对照组（P<0.05）。经治疗，两组阴道健康评分、LSIA评分均较治疗前显著升高，而SAS评分均显著降低（P<0.05）；治疗后，治疗组阴道健康评分、LSIA评分显著高于对照组，而SAS评分显著低于对照组（P<0.05）。经治疗，两组患者血清白细胞介素-8（IL-8）、白细胞介素-13（IL-13）、白细胞介素-2（IL-2）、肿瘤坏死因子-α（TNF-α）、单核细胞趋化蛋白1（MCP-1）水平均较治疗前显著降低（P<0.05）；治疗组这些血清学指标显著低于对照组（P<0.05）。结论 百艾洗液联合奥硝唑阴道栓治疗滴虫性阴道炎具有较好的临床疗效，可显著改善临床症状，促进阴道健康改善，降低机体炎症反应，具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy of Baiai Lotion combined with Ornidazole Vaginal Suppositories in treatment of trichomonas vaginitis. Methods Patients (150 cases) with trichomonas vaginitis in Luohe Central Hospital from February 2020 to June 2020 were selected as the research objects, and they were divided into control group (75 cases) and treatment group (75 cases) according to the order of treatment. Patients in the control group were given Ornidazole Vaginal Suppositories, Ornidazole Vaginal Suppositories were embolized deep into the vagina with gloves after vulva was cleaned every night, one Ornidazole Vaginal Suppositories/time, once daily. Patients in the treatment group were given Baiai Lotion on the basis of the control group, dilute 20 mL with warm water to 200 mL, and rinsed with a vaginal irrigator, twice daily. Both groups were treated consecutively for 10 days. The clinical efficacy of the two groups was compared, and the symptom disappearance time, relevant scores and serological indicators of the two groups were observed before and after treatment. Results After treatment, the total effective rate in the treatment group was 98.67%, significantly higher than 85.33% in the control group (P<0.05). After treatment, the disappearance time of vulva pruritus, abdominal pain, vulva burning pain, and abnormal leucorrhea in the treatment group was significantly shorter than that in the control group (P<0.05). After treatment, the vaginal health score and LSIA score in both groups were significantly higher than those before treatment, but SAS score was significantly lower (P<0.05). After treatment, vaginal health score and LSIA score in the treatment group were significantly higher than those in the control group, but SAS score was significantly lower than that in the control group (P<0.05). After treatment, the serum levels of IL-8, IL-13, IL-2, TNF-α and MCP-1 in the two groups were significantly lower than those before treatment (P<0.05). After treatment, these serological indexes in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Baiai Lotion combined with Ornidazole Vaginal Suppositories has good clinical efficacy in treatment of trichomonas vaginitis, and can significantly improve the clinical symptoms, also can promote the improvement of vaginal health, reduce the body's inflammatory response, which has certain clinical application value.

R984

河南省医学科技攻关计划项目（2018021025）