目的 探讨枫蓼肠胃康颗粒联合枸橼酸阿尔维林胶囊治疗腹泻型肠易激综合征的临床疗效。方法 选取2019年3月-2020年3月在商丘市第一人民医院就诊的112例肠易激综合征患者为研究对象，将全部患者根据随机数字表法分为对照组和治疗组，每组各56例。对照组口服枸橼酸阿尔维林胶囊，60 mg/次，3次/d。治疗组在对照组治疗的基础上温水冲服枫蓼肠胃康颗粒，8 g/次，3次/d。两组连续治疗8周。观察两组的临床疗效，比较两组腹痛、腹泻、腹胀消失时间，白细胞介素-6（IL-6）、白细胞介素-17（IL-17）、肿瘤坏死因子-α（TNF-α）水平和大便性状、排便频率评分。结果 治疗后，治疗组的总有效率（91.07%）明显高于对照组（76.79%），差异有统计学意义（P<0.05）。治疗后，治疗组腹痛、腹泻、腹胀的消失时间明显短于对照组，差异有统计学意义（P<0.05）。治疗后，两组的IL-6、IL-17、TNF-α水平显著降低（P<0.05）；且治疗组的IL-6、IL-17、TNF-α水平低于对照组（P<0.05）。治疗后，两组大便性状和排便频率评分显著降低（P<0.05）；且治疗组的大便性状和排便频率评分低于对照组（P<0.05）。结论 枫蓼肠胃康颗粒联合枸橼酸阿尔维林胶囊可提高肠易激综合征的疗效，可改善临床症状，减轻炎症反应。

Objective To investigate the clinical efficacy of Fengliao Changweikang Granules combined with Alverine Citrate Capsules in treatment of irritable bowel syndrome. Methods Patients (112 cases) with irritable bowel syndrome in Shangqiu First People's Hospital from March 2019 to March 2020 were randomly divided into control and treatment groups, and each group had 56 cases. Patients in the control group were po administered with Alverine Citrate Capsules, 60 mg/time, three times daily. Patients in the treatment group were po administered with Fengliao Changweikang Granules on the basis of the control group, 8 g/time, three times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacies were evaluated, and the disappearance time of abdominal pain, diarrhea and abdominal distension, the levels of IL-6, IL-17, and TNF-α, and the defecation characteristics scores and the defecation frequency scores in two groups were compared. Results After treatment, the total effective rate of the treatment group (91.07%) was significantly higher than that of the control group (76.79%), and the difference was statistically significant (P<0.05). After treatment, the disappearance time of abdominal pain, diarrhea and abdominal distension in the treatment group were significantly shorter than that of the control group (P<0.05). After treatment, the levels of IL-6, IL-17, and TNF-α in two groups were significantly lower (P<0.05), and the levels of IL-6, IL-17, and TNF-α in the treatment group were lower than those in the control group (P<0.05). After treatment, defecation characteristics scores and defecation frequency scores in two groups were significantly lower than those in the control group (P<0.05), and defecation characteristics scores and defecation frequency scores in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Fengliao Changweikang Granules combined with Alverine Citrate Capsules has clinical curative effect in treatment of irritable bowel syndrome, can improve clinical symptoms, and reduce inflammatory reaction.

R975

河南省高等学校重点科研项目（19 A320028）