目的 探讨连花清瘟胶囊联合更昔洛韦眼用凝胶治疗单纯疱疹病毒性角膜炎的临床疗效。方法 选取2018年6月-2020年4月在河南大学第一附属医院就诊的82例单纯疱疹病毒性角膜炎患者作为实验对象，按照随机数字表法将82例患者分为对照组和治疗组，每组各41例。对照组给予更昔洛韦眼用凝胶，2滴/次，4次/d。治疗组在对照组治疗的基础上口服连花清瘟胶囊，4粒/次，3次/d。两组患者连续治疗14 d。观察两组患者的临床疗效，比较两组患者的干涩消失时间、畏光消失时间、充血消失时间、角膜愈合时间、角膜病损面积及泪液中氧化应激指标表皮生长因子（EGF）、丙二醛（MDA）、谷胱甘肽过氧化物酶（GSH-Px）水平。结果 治疗后，治疗组患者的总有效率为95.12%，对照组总有效率为80.49%，两组比较差异有统计学意义（P<0.05）。治疗后，治疗组的干涩消失时间、畏光消失时间、充血消失时间、角膜愈合时间均短于对照组，差异有统计学意义（P<0.05）。治疗后，两组的角膜病损面积显著降低（P<0.05）；治疗后治疗组的角膜病损面积低于对照组（P<0.05）。治疗后，两组泪液的EGF、GSH-Px水平明显升高，MDA水平明显降低（P<0.05）；治疗后治疗组泪液的EGF、GSH-Px水平高于对照组，MDA水平低于对照组（P<0.05）。结论 连花清瘟胶囊联合更昔洛韦眼用凝胶可提高单纯疱疹病毒性角膜炎的临床疗效，减轻临床症状，降低泪液氧化应激因子水平。

Objective To investigate the clinical effect of Lianhua Qingwen Capsules combined with Ganciclovir Ophthalmic Gel in treatment of herpes simplex keratitis. Methods Patients (82 cases) with herpes simplex keratitis in the First Affiliated Hospital of Henan University from June 2018 to April 2020 were randomly divided into control and treatment groups, and each group had 41 cases. Patients in the control group were given Ganciclovir Ophthalmic Gel, 2 drops/time, once daily. Patients in the treatment group were po administered with Lianhua Qingwen Capsules on the basis of the control group, 4 grains/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and dry astringency disappearance time, photophobia disappearance time, hyperemia disappearance time, corneal healing time, corneal lesion areas, and the levels of oxidative stress index EGF, MDA, and GSH-P_X in two groups were compared. Results After treatment, the total effective rate of the treatment group was 95.12%, and that of the control group was 80.49%, and the difference between two groups was statistically significant (P<0.05). After treatment, the dry astringency disappearance time, photophobia disappearance time, hyperemia disappearance time, and corneal healing time of the treatment group were shorter than those of the control group, and the difference was statistically significant (P<0.05). After treatment, the corneal lesion area of two groups was significantly reduced (P<0.05). And after treatment, the corneal lesion area of the treatment group was lower than that of the control group (P<0.05). After treatment, the level of EGF and GSH-P_X in tear of two groups was significantly increased, but the levels of MDA in tear of two groups were significantly decreased (P<0.05). And after treatment, the level of EGF and GSH-P_X in tear of the treatment group was higher than those in the control group, while the levels of MDA in tear of the treatment group were lower than those in the control group (P<0.05). Conclusion Lianhua Qingwen Capsules combined with Ganciclovir Ophthalmic Gel can improve the clinical efficacy of herpes simplex keratitis, reduce the clinical symptoms, and reduce the level of oxidative stress factor in tears.

R988.1

开封市科技攻关项目（2003027）