目的 探讨舒冠颗粒联合单硝酸异山梨酯胶囊治疗冠心病心绞痛的临床疗效。方法 选取2018年4月-2020年3月在南阳市中心医院就诊的100例冠心病心绞痛患者，根据随机数字表法将100例患者分为对照组和治疗组，每组各50例。对照组口服单硝酸异山梨酯胶囊，20 mg/次，2次/d。治疗组在对照组治疗的基础上温水冲服舒冠颗粒，6 g/次，3次/d。两组患者连续治疗4周。观察两组临床疗效，比较两组的心绞痛发作频率、单次持续时间、硝酸甘油剂量，心功能指标和血液流变学指标。结果 治疗后，治疗组心绞痛总有效率（94.00%）明显高于对照组（80.00%），差异有统计学意义（P<0.05）。治疗后，治疗组心电图总有效率（88.00%）高于对照组（72.00%），差异有统计学意义（P<0.05）。治疗后，两组的心绞痛发作频率、单次持续时间、硝酸甘油剂量均显著降低，差异有统计学意义（P<0.05）；且治疗组的心绞痛发作频率、单次持续时间、硝酸甘油剂量均低于对照组，差异有统计学意义（P<0.05）。治疗后，两组患者的左心室射血分数（LVEF）、左心室收缩末期内径（LVESD）、心输出量（CO）均显著升高，差异有统计学意义（P<0.05）；且治疗组患者的LVEF、LVESD、CO高于对照组，差异有统计学意义（P<0.05）。治疗后，两组的血浆黏度、纤维蛋白原、血沉明显降低，差异有统计学意义（P<0.05）；且治疗组的血浆黏度、纤维蛋白原、血沉低于对照组，差异有统计学意义（P<0.05）。结论 舒冠颗粒联合单硝酸异山梨酯胶囊能显著提高冠心病心绞痛的疗效，可减轻心绞痛症状，改善血液流变学和心功能。

Objective To investigate the clinical effect of Shuguan Granules combined with Isosorbide Mononitrate Capsules in treatment of angina pectoris of coronary heart disease. Methods Patients (100 cases) with angina pectoris of coronary heart disease in Nanyang Central Hospital from April 2018 to March 2020 were randomly divided into control and treatment groups, and each group had 50 cases. Patients in the control group were po administered with Isosorbide Mononitrate Capsules, 20 mg/time, twice daily. Patients in the treatment group were po administered with Shuguan Granules on the basis of the control group, 6 g/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and the attack frequency and the single duration of angina pectoris, the nitroglycerin dose, the cardiac function indexes, and the hemorheological indexes in two groups were compared. Results After treatment, the total effective rate of angina pectoris in the treatment group (94%) was significantly higher than that in the control group (80%), and the difference was statistically significant (P<0.05). After treatment, the total effective rate of ECG in the treatment group (88.00%) was higher than that in the control group (72.00%), and the difference was statistically significant (P<0.05). After treatment, the attack frequency and the single duration of angina pectoris, and the nitroglycerin dose of the two groups were significantly reduced, and the difference was statistically significant (P<0.05). And the attack frequency and the single duration of angina pectoris, and the nitroglycerin dose in the treatment group were lower than those in the control group, and the difference was statistically significant (P<0.05). After treatment, LVEF, LVESD, and CO of two groups were significantly increased, and the difference was statistically significant (P<0.05). And LVEF, LVESD, CO of the treatment group were higher than those of the control group, and the difference was statistically significant (P<0.05). After treatment, plasma viscosity, fibrinogen, and erythrocyte sedimentation rate of two groups were significantly decreased (P<0.05), and the plasma viscosity, fibrinogen and erythrocyte sedimentation rate of the treatment group were lower than those of the control group (P<0.05). Conclusion Shuguan Granules combined with Isosorbide Mononitrate Capsules can significantly improve the curative effect of angina pectoris, relieve the symptoms of angina pectoris, improve hemorheology and cardiac function.

R972

河南省医学科技攻关计划联合共建项目（2018020852）