柚皮素是一种具有多种生物活性的天然黄酮类化合物，具有抗炎、抗氧化、抗肿瘤等多种药理作用。随着现代分子生物技术和纳米技术的进步，越来越多的研究对柚皮素进行纳米化处理，并且在提高溶解度、改善吸收、提高靶向性、提高抗肿瘤活性、降低不良反应等方面取得了一定进展。通过查阅国内外文献，对柚皮素纳米制剂的药理作用研究进行综述，为其后续研发提供必要的思路和参考。

Naringenin is a kind of natural flavonoid compound with multiple biological activities and it has the pharmacological effects of anti-inflammatory, antioxidation, antitumor effects and so on. With the progress of modern molecular biotechnology and nanotechnology, more and more researches have been performed on naringenin nano crystallization, and some progress has been made in improving the solubility, absorption and targeting, enhancing anti-tumor activity, reducing adverse reactions. In this paper, we summarized pharmacology of naringenin nanoparticles on the basis of domestic and overseas literature, and provided necessary ideas and references for the future development.

R977

国家重点研发计划中医药现代化研究重点专项（2018YFC1706700）；黑龙江省自然科学基金资助项目（H201472）