目的 观察黄芩茎叶解毒胶囊联合阿奇霉素治疗急性咽炎的临床效果。方法 选择2017年4月—2019年6月在天津市泰达医院治疗的急性咽炎患者131例，随机分为对照组（65例）和治疗组（66例）。对照组口服阿奇霉素片，首日剂量0.5 g，第2～5天剂量为0.25 g。治疗组在对照组的基础上口服黄芩茎叶解毒胶囊，3粒/次，3次/d。两组患者均连续治疗5 d。观察两组患者临床疗效，同时比较治疗前后两组患者血清白细胞介素-6（IL-6）、C反应蛋白（CRP）和IL-1β水平及临床症状消失时间。结果 治疗后，对照组和治疗组临床有效率分别为78.46%、93.94%，两组比较差异有统计学意义（P<0.05）。治疗后，两组IL-6、CRP和IL-1β水平均明显降低（P<0.05），且治疗组患者明显低于对照组（P<0.05）。治疗后，治疗组患者临床症状消失时间明显比对照组短（P<0.05）。结论 黄芩茎叶解毒胶囊联合阿奇霉素治疗急性咽炎，可快速改善患者临床症状，缓解机体炎症反应水平。

Objective To observe the clinical effect of Huangqin Jingye Jiedu Capsules combined with azithromycin in treatment of acute pharyngitis. Methods Patients (131 cases) with acute pharyngitis in Tianjin TEDA Hospital from April 2017 to June 2019 were randomly divided into control (65 cases) and treatment (66 cases) groups. Patients in the control group were po administered with Azithromycin Tablets, the first day dose was 0.5 g, 0.25 g for the 2nd day to the fifth day. Patients in the treatment group were po administered with Huangqin Jingye Jiedu Capsules on the basis of the control group, 3 grains/time, three times daily. Patients in two groups were treated for 5 d. After treatment, the clinical efficacy was evaluated, and the serum levels of IL-6, CRP and IL-1β, and the disappearance time of clinical symptoms in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 78.46% and 93.94%, respectively, and there were differences between two groups (P<0.05). After treatment, the serum levels of IL-6, CRP and IL-1β in two groups were significantly decreased (P<0.05), and which in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the disappearance time of clinical symptoms in the treatment group were significantly earlier than that in the control group (P<0.05). Conclusion Huangqin Jingye Jiedu Capsules combined with azithromycin in treatment of acute pharyngitis can rapidly improve the clinical symptoms, and relieve the level of inflammatory response.

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