[关键词]
[摘要]
目的 研究齿痛消炎灵颗粒联合奥硝唑片治疗智齿冠周炎的临床疗效。方法 选取2018年3月—2020年3月在焦作煤业(集团)有限责任公司中央医院治疗的120例智齿冠周炎患者(患牙141颗),随机分为对照组(60例,患牙70颗)和治疗组(60例,患牙71颗)。对照组患者给予奥硝唑片,1片/次(研磨成粉,制成糊状膏体,采用牙周探针涂入盲袋内),1次/d。治疗组在对照组基础上口服齿痛消炎灵颗粒,1袋/次,3次/d。两组患者接受治疗时间为10 d。观察两组患者临床疗效,比较两组的临床症状缓解时间、牙周指标、口腔健康影响程度量表(OHIP-14)评分和视觉模拟评分法(VAS)评分、龈沟液炎性因子水平。结果 治疗后,治疗组总有效率(96.67%)显著高于对照组(78.33%)(P<0.05)。治疗后,治疗组牙龈红肿、牙龈疼痛、牙龈出血消失时间明显短于对照组(P<0.05)。治疗后,两组牙龈指数(GI)、牙菌斑指数(PLI)、牙周袋深度(PD)和龈沟出血指数(SBI)显著降低(P<0.05);且治疗组牙周指标水平降低较明显(P<0.05)。治疗后,两组OHIP-14评分和VAS评分均显著降低(P<0.05);且治疗组OHIP-14评分和VAS评分降低较明显(P<0.05)。治疗后,两组龈沟液白细胞介素-1β(IL-1β)和超敏C-反应蛋白(hs-CRP)水平显著降低(P<0.05);且治疗组IL-1β和hs-CRP水平较低较明显(P<0.05)。结论 齿痛消炎灵颗粒联合奥硝唑片治疗智齿冠周炎具有较好的治疗效果,可改善临床症状,降低患者龈沟液炎性因子水平。
[Key word]
[Abstract]
Objective To study the effect of Chitong Xiaoyanling Granules combined with Ornidazole Tablets in treatment of pericoronitis. Methods Patients (120 cases, 141 teeth) with pericoronitis in Central Hospital of Jiaozuo Coal Industry (Group) Co., Ltd., from March 2018 to March 2020 were randomly divided into the control group (60 cases, 70 teeth) and the treatment group (60 cases, 71 teeth). Patients in the control group were given Ornidazole Tablets, 1 tablet/time (The drug was ground into powder and made into paste, which was applied into the blind bag by the periodontal probe), once daily. Patients in the treatment group were po administered with Chitong Xiaoyanling Granules on the basis of the control group, 1 bag/time, three times daily. Patients in two groups were treated for 10 d. After treatment, the clinical efficacies were evaluated, and the clinical symptom relief time, the periodontal index, the OHIP-14 score, the VAS score, the inflammatory factors in the gingival crevicular fluid of two groups were compared. Results After treatment, the total effective rate of the treatment group (96.67%) was significantly higher than that of the control group (78.33%) (P<0.05). After treatment, the disappearance times of gingival redness, gingival pain and gingival bleeding in the treatment group was significantly shorter than those in the control group (P<0.05). After treatment, the GI, PLI, PD, and SBI in two groups were significantly decreased (P<0.05), and the periodontal indexes in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the OHIP-14 score and the VAS score of two groups were significantly decreased (P<0.05), and the OHIP-14 score and the VAS score of the treatment group were significantly lower than those of the control group (P<0.05). After treatment, the levels of IL-1β and hs-CRP in the gingival crevicular fluid of two groups were significantly decreased (P<0.05), and the levels of IL-1β and hs-CRP in the gingival crevicular fluid of the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Chitong Xiaoyanling Granules combined with Ornidazole Tablets has clinical curative effect in treatment of pericoronitis, can improve the clinical symptoms, and reduce the level of inflammatory factors in gingival crevicular fluid.
[中图分类号]
R988.2
[基金项目]
河南省医学科技攻关计划省部共建项目(SB201901088)