目的 探讨妇科再造胶囊联合地屈孕酮片治疗月经不调的临床疗效。方法 选取2019年5月—2020年5月在南阳市卧龙区妇幼保健院进行诊治的98例月经不调患者为研究对象，根据就诊的顺序分为对照组和治疗组，每组各49例。对照组口服地屈孕酮片，10 mg/次，2次/d；治疗组在对照组基础上口服妇科再造胶囊，6粒/次，2次/d。两组均连续治疗1个月经周期。观察两组的临床疗效，比较两组相关评分、临床症状改善时间、性激素水平。结果 经治疗，治疗组总有效率97.96%显著高于对照组的81.63%（P<0.05）。经治疗，两组QOL评分、HPS评分、KPS评分均较治疗前显著升高，而PBAC评分均显著下降（P<0.05）；治疗后，治疗组这些相关评分改善优于对照组（P<0.05）。经治疗，治疗组在腰骶酸痛、少气懒言、五心烦热、神疲乏力等症状改善时间上均显著短于对照组（P<0.05）。经治疗，两组血清卵泡生成激素（FSH）、黄体生成激素（LH）均较治疗前显著降低，而雌二醇（E₂）水平均显著升高（P<0.05）；且治疗后，治疗组性激素水平改善优于对照组（P<0.05）。结论 妇科再造胶囊联合地屈孕酮治疗月经不调具有较好的临床疗效，可有效改善患者临床症状，改善性激素水平，具有一定的临床推广应用价值。

Objective To investigate the clinical effect of Fuke Zaizao Capsules combined with dydrogesterone in treatment of irregular menstruation. Methods 98 Patients with irregular menstruation who were treated in Nanyang Wolong District Maternal and Child Health Hospital from May 2019 to May 2020 were selected as the research objects, and they were divided into control group and treatment group according to the order of treatment, with 49 cases in each group. The control group was po administered with Dydrogesterone Tablets, 10 mg/time, twice daily. The treatment group was po administered with Fuke Zaizao Capsules on the basis of the control group, 6 grains/time, twice daily. Both groups were treated continuously for one menstrual cycle. The clinical efficacy of the two groups was observed, and the relevant scores, improvement time of clinical symptoms and sex hormone levels of the two groups were compared. Results After treatment, the total effective rate of 97.96% in the treatment group was significantly higher than that of 81.63% in the control group (P<0.05). After treatment, QOL score, HPS score and KPS score in both groups were significantly increased compared with those before treatment, while PBAC score was significantly decreased (P<0.05). After treatment, these scores improved better in the treatment group than in the control group (P<0.05). After treatment, the improvement time of lumbosacral soreness, little energy and lazy speech, five distractibility and heat, mental fatigue and other symptoms in the treatment group was significantly shorter than that in the control group (P<0.05). After treatment, serum follicle-generating hormone (FSH) and luteinizing hormone (LH) in the two groups were significantly lower than that before treatment, while the levels of estradiol (E₂) were significantly higher (P<0.05). After treatment, the improvement of sex hormone level in the treatment group was better than that in the control group (P<0.05). Conclusion Fuke Zaizao Capsules combined with dydrogesterone has a good clinical effect in treatment of irregular menstruation, and can effectively improve the clinical symptoms of patients, improve the level of sex hormones, which has certain clinical application value.

R984

河南省科技计划发展项目（162102310231）