[关键词]
[摘要]
目的 探讨冬菀止咳颗粒联合头孢克洛治疗小儿急性支气管炎的临床疗效。方法 选取2018年5月—2020年5月在郑州市金水区总医院就诊的急性支气管炎患儿98例,根据用药的差别分为对照组(49例)和治疗组(49例)。对照组口服头孢克洛片,6.67 mg/kg,3次/d,严重者可增至13.33 mg/kg,但不得超过1 g/d;治疗组在对照组的基础上口服冬菀止咳颗粒,5 g/次,3次/d。两组患者均经7 d治疗。观察两组患者临床疗效,同时比较治疗前后两组患者中医症候积分及血清超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、白细胞介素-10(IL-10)、γ干扰素(IFN-γ)和淀粉样蛋白A(SAA)水平。结果 治疗后,对照组患儿临床有效率为81.63%,显著低于治疗组的97.96%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患儿中医症候积分显著下降(P<0.05),且治疗组明显低于对照组(P<0.05)。治疗后,两组患儿血清hs-CRP、SAA、IL-1β、TNF-α水平均明显下降,而IL-10和IFN-γ水平均明显升高(P<0.05),且治疗组患儿这些血清学指标显著优于对照组(P<0.05)。结论 冬菀止咳颗粒联合头孢克洛片可明显改善小儿急性支气管炎临床症状,具有一定的临床推广应用价值。
[Key word]
[Abstract]
Objective To investigate the clinical effect of Dongwan Zhike Granules combined with cefaclor in treatment of children with acute bronchitis. Methods Children (98 cases) with acute bronchitis in Zhengzhou Jinshui District General Hospital from May 2018 to May 2020 were divided into control (49 cases) and treatment (49 cases) groups according to different treatments. Children in the control group were po administered with Cefaclor Tablets, 6.67 mg/kg, three times daily, the dose can be increased to 13.33 mg/kg for the serious cases, but less than 1 g/d. Children in the treatment group were po administered with Dongwan Zhike Granules on the basis of the control group, 5 g/time, three times daily. Children in two groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, and the TCM symptom score, and the serum level of hs-CRP, SAA, IL-1β, TNF-α, IL-10 and IFN-γ in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 81.63%, which was significantly lower than 97.96% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the TCM symptom score in two groups was significantly decreased (P<0.05), and which in the treatment group was significantly lower than that in the control group (P<0.05). After treatment, the serum levels of hs-CRP, SAA, IL-1β, and TNF-α in two groups were significantly decreased, but the levels of IL-10 and IFN-γ were significantly increased (P<0.05), and these indexes levels in the treatment group were significantly better than those in the control group (P<0.05). Conclusion Dongwan Zhike Granules combined with cefaclor can significantly improve the clinical symptoms of children with acute bronchitis, which has a certain clinical application value.
[中图分类号]
R974
[基金项目]
河南省医学科技攻关计划项目(201403258)