目的 探究白芷的最佳水提取工艺。方法 以干浸膏得率、欧前胡素转移率、综合评分为评价指标，采用单因素试验考察浸泡时间、提取时间、提取次数和加水倍数对提取效果的影响；根据单因素试验结果，采用L₉（3⁴）正交试验法对浸泡时间、提取时间、提取次数和加水倍数进一步优化，并对优化工艺进行验证。结果 优化后的提取工艺为加12倍水，提取3次，每次提取0.5 h。优化后的工艺所得干浸膏的平均得率为24.25%，欧前胡素平均转移率为17.24%。结论 优化的水提取工艺稳定、可行，可用于白芷的水提取。

Objective To explore the best water extraction process of Angelicae Dahuricae Radix. Methods Taking dry extract yield, imperatorin transfer rate and the comprehensive score as evaluation indicators, a single factor test was used to investigate the effects of soaking time, extraction time, extraction times, and water addition multiples on the extraction effect. L₉(3⁴) orthogonal test method was used to further optimize the soaking time, extraction time, extraction times, and water addition ratio, and to verify the optimization process. Results The optimized extraction process was adding 12 times of water, extract 3 times, and each extraction for 0.5 h. The verification test showed that the average yield of the dry extract obtained by the optimized process was 24.25%, and the average transfer rate of imperatorin was 17.24%. Conclusion The optimized water extraction process is stable and feasible. It can be used for the water extraction of Angelicae Dahuricae Radix.

R977

安徽省科技重大专项（17030801009）