目的 探讨醋氯芬酸缓释片治疗膝骨关节炎的临床疗效。方法 选取2018年1月-2019年12月在天津市第一中心医院治疗的96例膝骨关节炎患者作为研究对象，按照不同治疗方法将所有患者分为常规片组、缓释片组，每组各48例。常规片组口服醋氯芬酸片，100 mg/次，2次/d。缓释片组口服醋氯芬酸缓释片，200 mg/次，1次/d。两组患者连续治疗4周。观察两组的临床疗效，比较两组治疗前后视觉模拟评分法（VAS）评分、关节功能评分、日常生活能力评分。结果 治疗后，缓释片组患者的总有效率（97.9%）明显高于常规片组（87.5%），两组数据组间差异具有统计学意义（P<0.05）。治疗后，两组患者VAS评分、关节功能评分、日常生活能力评分均显著降低（P<0.05），且缓释片组患者VAS评分、关节功能、日常生活能力评分明显低于常规片组（P<0.05）。结论 醋氯芬酸缓释片治疗骨关节炎具有较好的临床疗效，能够缓解患者疼痛，改善患者关节功能、日常生活能力。

Objective To explore the clinical effects of Aceclofenac Sustained-release Tablets in treatment of knee osteoarthritis. Methods Patients (96 cases) with knee osteoarthritis in Tianjin First Center Hospital from January 2018 to December 2019 were randomly divided into conventional tablets and sustained-release tablets groups, and each group had 48 cases. Patients in the conventional tablets group were po administered with Aceclofenac Tablets, 100 mg/time, twice daily. Patients in the sustained-release tablets group were po administered with Aceclofenac Sustained-release Tablets on the basis of the conventional tablets group, 200 mg/time, once daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and VAS scores, joint function scores, and activity of daily living scores in two groups were compared. Results After treatment, the total effective rate of the sustained-release tablets group (97.9%) was significantly higher than that of the conventional tablets group (87.5%), and there was difference between two groups (P < 0.05). After treatment, VAS scores, joint function scores, and activity of daily living scores of two groups were significantly decreased (P < 0.05), and VAS scores, joint function scores, and activity of the sustained-release tablets group were significantly lower than those of the conventional tablets group (P < 0.05). Conclusion Aceclofenac Sustained-release Tablets has clinical curative effect in treatment of knee osteoarthritis, can relieve the pain of patients, improve the joint function and daily living ability of patients, which has a certain clinical application value.

R977