[关键词]
[摘要]
目的 观察盘龙七片联合骨瓜提取物注射液治疗股骨颈骨折恢复期患者的临床效果。方法 选择2016年1月-2019年10月在常州市武进中医医院治疗的股骨颈骨折患者65例,随机分成对照组(33例)和治疗组(32例)。对照组静脉滴注骨瓜提取物注射液,50 mg加入生理盐水250 mL,1次/d。治疗组在对照组基础上口服盘龙七片,3片/次,3次/d。两组均连续治疗1个月。观察两组患者临床疗效,同时比较治疗前后两组患者视觉模拟评分(VAS)和Oswestry功能障碍指数问卷表(ODI)评分,及骨形态发生蛋白-2(BMP-2)、碱性磷酸酶(ALP)、骨钙素(BGP)、神经生长因子(NGF)、血小板衍生生长因子(PDGF)和胰岛素样生长因子(IGF-1)水平。结果 治疗后,对照组和治疗组临床有效率分别为75.76%、93.75%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者VAS、ODI评分均显著降低(P<0.05),且治疗组明显比对照组低(P<0.05)。治疗后,两组患者BMP-2、ALP、BGP、NGF、PDGF和IGF-1水平均显著升高(P<0.05),且治疗组明显比对照组高(P<0.05)。结论 盘龙七片联合骨瓜提取物注射液治疗股骨颈骨折恢复期患者,可促进患者骨折愈合,改善骨代谢水平,调节细胞因子,降低患者疼痛和术后并发症,改善功能障碍。
[Key word]
[Abstract]
Objective To observe the clinical effect of Panlongqi Tables combined with Cervus and Cucumis Polypeptide for injection in treatment of the recovery period of femoral neck fracture. Methods Patients (65 cases) with recovery period of femoral neck fracture in Wujin Hospital of TCM from January 2016 to October 2019 were randomly divided into control (33 cases) and treatment (32 cases) groups. Patients in the control group were iv administered with Cervus and Cucumis Polypeptide for injection, 50 mg added into normal saline 250 mL, once daily. Patients in the treatment group were po administered with Panlongqi Tables on the basis of the control group, 3 tablets/time, three times daily. Patients in two groups were treated for 1 month. After treatment, the clinical efficacy was evaluated, and the VAS and ODI scores, and the levels of BMP-2, ALP, BGP, NGF, PDGF and IGF-1 in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 75.76% and 93.75% respectively, and there were differences between two groups (P < 0.05). After treatment, the VAS and ODI scores in two groups were significantly decreased (P < 0.05), and these scores in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, the levels of BMP-2, ALP, BGP, NGF, PDGF and IGF-1 in two groups were significantly increased (P < 0.05), and these indicators levels in the treatment group were significantly higher than those in the control group (P < 0.05). Conclusion Panlongqi Tables combined with Cervus and Cucumis Polypeptide for injection in treatment of the recovery period of femoral neck fracture can promote fracture healing, improve bone metabolism, regulate cytokines, reduce pain and postoperative complications, and improve functional dysfunction.
[中图分类号]
R977
[基金项目]