目的 探讨齿痛消炎灵联合多西环素治疗慢性牙周炎的临床疗效。方法 选取2019年5月-2020年5月濮阳市第三人民医院收治的慢性牙周炎患者110例（139颗患牙），随机分为对照组（55例69颗牙）和治疗组（55例70颗牙）。对照组口服盐酸多西环素片，0.1 g/次，1次/d；治疗组在对照组基础上口服齿痛消炎灵颗粒，10 g/次，3次/d。两组均连续治疗4周。比较两组的临床疗效，观察两组牙周指标、外周血细胞因子水平、基质金属蛋白酶2（MMP-2）、基质金属蛋白酶组织抑制因子2（TIMP-2）的变化情况。结果 治疗后，治疗组的总有效率是94.55%，显著高于对照组的78.18%（P<0.05）。治疗后，两组口腔内牙周袋深度（PD）、菌斑指数（PLI）、出血指数（BI）、附着丧失（AL）和牙槽骨吸收（ABL）显著低于同组治疗前（P<0.05）；治疗组治疗后这些牙周指标明显低于对照组（P<0.05）。治疗后，两组患者TNF-α、IL-6和HMGB水平明显低于同组治疗前，而IL-10显著提高（P<0.05）；治疗组治疗后这些外周血中细胞因子水平改善优于对照组（P<0.05）。治疗后，两组MMP-2、TIMP-2、MMP-2/TIMP-2比值明显低于同组治疗前水平（P<0.05）；治疗后治疗组MMP-2、TIMP-2、MMP-2/TIMP-2比值明显低于对照组（P<0.05）。结论 齿痛消炎灵联合多西环素治疗慢性牙周炎疗效明显，可有效地降低炎症水平，从根本上改善牙周指标和基质金属蛋白酶，具有一定的临床推广应用价值。

Objective To investigate the curative effect of Chitong Xiaoyanling Granules combined with doxycycline in treatment of chronic periodontitis. Methods 110 Patients (139 teeth) with chronic periodontitis admitted to the Third People's Hospital of Puyang from May 2019 to May 2020 were randomly divided into the control group (55 cases with 69 teeth) and the treatment group (55 cases with 70 teeth). The control group was po administered with Doxycycline Hyclate Tablets 0.1 g/time, once daily. The treatment group was po administered with Chitong Xiaoyanling Granules on the basis of the control group, 10 g/time, 3 times daily. Both groups were treated continuously for 4 weeks. The clinical efficacy of the two groups was compared, and the changes of periodontal indexes, peripheral blood cytokine levels, matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase tissue inhibitor-2 (TIMP-2) in the two groups were observed. Results After treatment, the total effective rate of the treatment group was 94.55%, significantly higher than that of the control group 78.18% (P < 0.05). After treatment, the periodontal pocket depth (PD), plaque index (PLI), bleeding index (BI), attachment loss (AL) and alveolar bone resorption (ABL) in the two groups were significantly better than those before treatment (P < 0.05). These periodontal indexes in the treatment group were significantly better than those in the control group (P < 0.05). After treatment, the levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and high mobility group protein B (HMGB) in the two groups were significantly lower than those before treatment, but IL-10 was significantly higher (P < 0.05). After treatment, the level of cytokines in peripheral blood of the treatment group was better than that of the control group. After treatment, the MMP-2, TIMP-2 and MMP-2/TIMP-2 ratios in the two groups were significantly lower than those before treatment (P < 0.05). After treatment, the MMP-2, TIMP-2 and MMP-2/TIMP-2 ratios in the treatment group were significantly lower than those in the control group (P < 0.05). Conclusion Chitong Xiaoyanling Granules combined with doxycycline has obvious curative effect in treatment of chronic periodontitis, and can effectively reduce inflammation levels, and also can fundamentally improve periodontal indexes and matrix metalloproteinase, which has a certain clinical application value.

R988.2

濮阳市科技计划项目（1805076）